Oxidative stress and histological changes in Corbicula fluminea exposed to nano-Al13 and monomeric Al coagulants
Oxidative stress and histological changes in Corbicula fluminea exposed to nano-Al13 and monomeric Al coagulants
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纳米Al-13和单体Al凝固剂作用下河蚬的氧化应激和组织学变化
DOI：
10.1039/c9en00320g
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发表时间：
2019-09-01
影响因子：
7.3
通讯作者：
Feng，Chenghong
中科院分区：
文献类型：
--
作者：
Wu，Yuehan;Gu，Erxue;Feng，Chenghong
这是首次全面分析铝混凝剂对河蚬的虹吸效率、抗氧化防御系统和组织学改变的毒性。铝混凝剂以多核铝（如纳米Al13）和单核铝（Alm）的形式广泛存在于水处理厂出水和天然水中。结果表明，Alm比纳米Al13混凝剂对虹吸的抑制作用更强。对于所有选定的酶指标，纳米Al13对消化腺的诱导作用较强烈，而Alm对鳃的诱导作用较明显。 Alm和纳米Al13均可扩大消化管管腔，减少消化管上皮厚度，但纳米Al13对细胞膜的损伤更为严重。从显微镜观察到的明亮团簇推断，颗粒状纳米Al13主要通过吞咽进入消化腺，而鳃过滤是离子Alm进入蛤体的另一种方法。纳米Al13的存在以及与GSH相关的酶（例如GST和GR）的抑制导致细胞膜的损伤。对于这两种铝混凝剂，浓度越高，影响越负面。作为一种有效的混凝剂，PACl的毒性不容忽视。
This is the first study to comprehensively analyze the toxicity of Al coagulants, which are widely present in the effluent of water treatment plants and in natural water in the form of polynuclear Al (e.g., nano-Al13) and mononuclear Al (Alm), on the siphoning efficiency, antioxidant defense system and histological alterations of Corbicula fluminea. The results showed that Alm had a stronger inhibitory effect on siphoning than the nano-Al13 coagulant. For all the selected enzyme indexes, induction by nano-Al13 was more intense in the digestive gland, while that by Alm was more obvious in the gills. Either Alm or nano-Al13 can enlarge the tubule lumen and reduce the thickness of the epithelia of digestive tubules, but nano-Al13 caused more severe damage to the cellular membrane. Inferred from the bright clusters observed by microscopy, granular nano-Al13 enters the digestive gland mainly via swallowing, while gill filtration is another method by which the ionic Alm can enter the clam body. The presence of nano-Al13 and inhibition of enzymes associated with GSH, such as GST and GR, led to the damage of cell membranes. For both Al coagulants, the influence of higher concentrations is more negative. As an effective coagulant, the toxicity of PACl cannot be ignored.