INJURY-INDUCED REORGANIZATION OF SOMATOSENSORY CORTEX IS ACCOMPANIED BY REDUCTIONS IN GABA STAINING
INJURY-INDUCED REORGANIZATION OF SOMATOSENSORY CORTEX IS ACCOMPANIED BY REDUCTIONS IN GABA STAINING
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DOI：
10.3109/08990229109144757
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发表时间：
1991-01-01
影响因子：
0.9
通讯作者：
KAAS, JH
中科院分区：
文献类型：
--
作者：
GARRAGHTY, PE;LACHICA, EA;KAAS, JH
当一部分初级躯体感觉皮层被周围神经切断剥夺其正常输入时，在周围皮层中代表的完整皮肤表面在2个月内激活被剥夺的区域。我们发现，这种皮质重组伴随着显着减少γ-氨基丁酸（GABA）的抗体染色的剥夺部门的皮质神经损伤存活2-5个月的猴子。与此相反，有没有明显的变化，细胞色素氧化酶的反应性在剥夺皮质的这些相同的猴子。抑制水平的降低可以使以前未表达的连接变得有效。因此，GABA表达的调节似乎是维持和改变皮质表征的一种机制。
When a portion of primary somatosensory cortex is deprived of its normal inputs by peripheral nerve transection, intact skin surfaces represented in surrounding cortex come to activate the deprived zone within 2 months. We found that this cortical reorganization was accompanied by a marked decrease in the antibody staining of gamma-aminobutyric acid (GABA) within the deprived sector of cortex in monkeys surviving nerve injury for 2-5 months. In contrast, there were no apparent changes in cytochrome oxidase reactivity in the deprived cortex of these same monkeys. Reduced levels of inhibition could allow previously unexpressed connections to become potent. Thus, the regulation of the expression of GABA appears to be one mechanism for maintaining and altering cortical representations.