Is BCG associated with reduced incidence of COVID-19? A meta-regression of global data from 160 countries.
Is BCG associated with reduced incidence of COVID-19? A meta-regression of global data from 160 countries.
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DOI：
10.1016/j.cegh.2020.08.015
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发表时间：
2021-01
影响因子：
2.6
通讯作者：
Jeyaseelan L
中科院分区：
文献类型：
--
作者：
Joy M;Malavika B;Asirvatham ES;Sudarsanam TD;Jeyaseelan L
全球研究都在争先恐后地寻找阻止新冠肺炎威胁的疫苗。在这种情况下，预防严重形式结核病的卡介苗(BCG)正受到更多关注。我们研究的目的是确定卡介苗覆盖率和新冠肺炎在全球范围内的发病率之间的关系。这项研究包括了160个国家的数据。运用Meta回归方法估计卡介苗接种国家之间新冠肺炎病例发病率的差异。卡介苗覆盖率被归类为≤70%，>；70%，没有接种疫苗。调整了人口密度、收入群体、纬度和各国15-及65岁以上年龄组人口占总人口的比例等因素进行了分析。与报告没有覆盖的国家相比，拥有≤70%卡介苗覆盖率的国家报告的每10,000人口新冠肺炎感染减少6.5(95%CI：−8.4to−4.5)。那些有70%覆盖率的国家报告说，与那些没有卡介苗国家的国家相比，每10,000人感染人数减少了10.1(95%可信区间：−11.4到−8.7)。我们的分析表明，如果卡介苗覆盖率超过70%，卡介苗与新冠肺炎感染的减少有关。按地区进行的分析也得出了类似的结论，中东和北非地区除外。
Global research is running towards to find a vaccine to stop the threat of the COVID-19. The Bacillus Calmette–Guérin (BCG) vaccine that prevents severe forms of tuberculosis is getting more attention in this scenario. The objective of our study was to determine the association between BCG vaccine coverage and incidence of COVID-19 at a national-level across the Globe. The data of 160 countries were included in the study. Meta-regression was done to estimate the difference in the incidence of COVID-19 cases between countries with BCG vaccination coverage. BCG coverage was categorized as ≤70%, >70% and no vaccination. The analyses were carried out by adjusting for factors such as population density, income group, latitude, and percentage of the total population under age groups 15–64 and above 65 years of each country. The countries that had ≤70% coverage of BCG vaccine reported 6.5 (95% CI: −8.4 to −4.5) less COVID-19 infections per 10,000 population as compared to countries that reported no coverage. Those that had >70% coverage reported 10.1 (95% CI: −11.4 to −8.7) less infections per 10,000 population compared to those with no BCG countries. Our analysis suggests that BCG is associated with reduced COVID-19 infections if the BCG vaccine coverage is over 70%. The region-wise analyses also suggested similar findings, except the Middle East and North African region.
影响因子：
5.2
作者：
Sawaya, Tania;Ballouz, Tala;Rizk, Nesrine
通讯作者：
Rizk, Nesrine
影响因子：
6.4
作者：
Aaby, Peter;Roth, Adam;Benn, Christine Stabell
通讯作者：
Benn, Christine Stabell