PREVALENCE OF SERUM AND MILK ANTIBODIES TO GIARDIA-LAMBLIA IN DIFFERENT POPULATIONS OF LACTATING WOMEN
PREVALENCE OF SERUM AND MILK ANTIBODIES TO GIARDIA-LAMBLIA IN DIFFERENT POPULATIONS OF LACTATING WOMEN
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DOI：
10.1093/infdis/152.5.1025
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发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
YOLKEN, RH
中科院分区：
文献类型：
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作者：
MIOTTI, PG;GILMAN, RH;YOLKEN, RH
我们使用酶联免疫吸附测定系统来比较不同人群中贾第鞭毛虫全身和局部抗体的流行率和水平。同时从德克萨斯州和墨西哥的哺乳期妇女身上采集系列血液和乳汁样本。 27 名墨西哥母亲的 153 份血清中，有 118 份 (77%) 存在针对兰氏杆菌的 IgG 抗体，但 28 名德克萨斯州母亲的 214 份血清中，只有 51 份 (24%) 存在 (P < .001)。兰伯利亚 IgG 抗体血清呈阳性，显示墨西哥的抗体水平显着高于德克萨斯州（0.325 .+-. 0.076 对比 0.219 .+-. 0.079 光密度单位）。在墨西哥人群的 153 个牛奶样本中，有 121 个 (79%) 发现了针对 G.ambalia 的分泌性 IgA 抗体，但在德克萨斯人群的 214 个样本中，只有 33 个 (15%) 存在 (P < .001)。墨西哥人群中兰氏杆菌的分泌性抗体水平也较高。该研究记录了生活在不同地区的个体对兰氏蓝氏菌的抗体反应存在很大差异。由于婴儿可以通过胎盘或母乳喂养获得兰氏贾第虫抗体，因此这种差异对于贾第鞭毛虫感染的相对保护可能很重要。
We used an enzyme-linked immunosorbent assay system to compare prevalence and levels of systemic and local antibody to Giardia lambia in different populations. Serial blood and milk samples were collected simultaneously from lactating women in Texas and Mexico. IgG antibody to G. lamblia was present in 118 (77%) of 153 sera from 27 Mexican mothers but in only 51 (24%) of 214 sera obtained from 28 Texan mothers (P < .001). Sera positive for IgG antibody to G. lamblia revealed antibody levels that were significantly higher in Mexico than in Texas (0.325 .+-. 0.076 vs. 0.219 .+-. 0.079 optical density units). Secretory IgA antibody to G. lamblia was found in 121 (79%) of 153 milk samples in the Mexican population, but in only 33 (15%) of 214 samples in the Texan population (P < .001). The levels of secretory antibody to G. lamblia also were higher in the Mexican population. The study documents a widely different antibody response to G. lamblia in individuals living in different areas. As antibodies to G. lamblia can be acquired by infants transplacentally or through breast-feeding, this difference might be important in the relative protection against giardial infection.