Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
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DOI：
10.7554/elife.49132
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发表时间：
2019-09-02
期刊：
影响因子：
7.7
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
Adams, Jenna N.;Maass, Anne;Jagust, William J.
Tau病理首先出现在老化大脑的经鼻内侧和前外侧内嗅皮质(Alec)。向阿尔茨海默病(AD)的转变被认为涉及淀粉样β蛋白(Aβ)促进tau通过神经连接传播。我们对比了Alec和后内侧EC(PmEC)的功能连接性(FC)，这两个EC的亚区在功能特化和皮质连接性方面存在差异，与Alec连接的皮质比pmEC连接的皮质显示更多tau沉积的假设进行了对比。我们使用静息状态的功能磁共振成像来测量FC，并使用PET来测量认知正常的老年人的tau和Aβ。与pmEC连接或非连接的皮质相比，tau在Alec连接的皮质中优先沉积，且连接越强，tau的沉积越多。Fc-tau关系与Aβ无关，尽管Aβ加强了Fc-tau关系。这些结果解释了衰老脑中新皮质tau沉积的解剖学特异性，揭示了正常衰老与AD演变之间的关系。
Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve amyloid-beta (A beta) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than pmEC-connected cortex. We used resting state fMRI to measure FC, and PET to measure tau and A beta in cognitively normal older adults. Tau preferentially deposited in alEC-connected cortex compared to pmEC-connected or non-connected cortex, and stronger connectivity was associated with increased tau deposition. FC-tau relationships were present regardless of A beta, although strengthened with A beta. These results provide an explanation for the anatomic specificity of neocortical tau deposition in the aging brain and reveal relationships between normal aging and the evolution of AD.