Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery
Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery
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DOI：
10.1016/s0168-3659(03)00217-7
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发表时间：
2003-08-28
影响因子：
10.8
通讯作者：
Torchilin, VP
中科院分区：
文献类型：
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作者：
Lukyanov, AN;Gao, ZG;Torchilin, VP
由与磷脂酰乙醇胺（PEG-PE）缀合的不同长度的聚乙二醇制备的胶束中负载有各种难溶性抗癌剂。 PEG-PE 胶束选择性地在植入小鼠的 Lewis 肺癌 (LLC) 肿瘤中积累。用肿瘤特异性抗体修饰胶束进一步提高了肿瘤积累的效率。 (C) 2003 Elsevier B.V. 保留所有权利。
Micelles prepared from polyethylene glycols of various lengths conjugated with phosphatidylethanolamine (PEG-PE) were loaded with various poorly soluble anticancer agents. PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation. (C) 2003 Elsevier B.V. All rights reserved.