Ontogeny of the Estrogen Receptor during Early Uterine Development
Ontogeny of the Estrogen Receptor during Early Uterine Development
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早期子宫发育过程中雌激素受体的个体发育
DOI：
10.1126/science.169.3940.76
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发表时间：
1970
期刊：
影响因子：
56.9
通讯作者：
J. Gorski
中科院分区：
文献类型：
--
作者：
James H. Clark;J. Gorski
在完整雌性大鼠和去势雌性大鼠中，子宫细胞质中每个细胞的雌激素结合位点数量在生命第 10 天时达到最大值。达到该峰值后，每个细胞的结合位点数量减少，并且该比例保持恒定，直到生命第 22 至 23 天。因此，雌激素结合蛋白的个体发育不依赖于卵巢的雌激素，并且可能是子宫细胞的自主特性。动物5至10日龄时蛋白质的沉降值和解离常数与22日龄动物相似，表明在整个出生后发育过程中都存在相同的蛋白质。
The number of estrogen binding sites in uterine cytoplasm on a per cell basis reaches a maximum by day 10 of life in both intact and castrate female rats. After this peak is reached, the number of binding sites per cell decreases, and the ratio remains constant until days 22 to 23 of life. Thus, the ontogeny of the estrogen binding protein is not dependent upon estrogen from the ovary and is probably an autonomous property of uterine cells. Sedimentation values and dissociation constants of the protein when the animals are 5 to 10 days of age are similar to those of the 22-day-old animal, indicating that the same protein is present throughout postnatal development.