REGULATION AND BIOLOGICAL FUNCTION OF HELMINTH-INDUCED CYTOKINE RESPONSES
REGULATION AND BIOLOGICAL FUNCTION OF HELMINTH-INDUCED CYTOKINE RESPONSES
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DOI：
10.1016/s0167-5699(05)80018-0
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发表时间：
1991-03-01
期刊：
影响因子：
--
通讯作者：
SHER, A
中科院分区：
文献类型：
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作者：
FINKELMAN, FD;PEARCE, EJ;SHER, A
寄生蠕虫感染的免疫学标志，即嗜酸性粒细胞增多症、肥大细胞增多症和IgE合成增加，似乎都是由来自CD 4 +T细胞的TH 2亚群的细胞因子诱导的：IgE产生由白细胞介素4（IL-4）刺激，嗜酸性粒细胞增多症由IL-5刺激，肥大细胞增多症由IL-3和IL-4刺激。在这里，Fred Finkelman及其同事认为，嗜酸性粒细胞肥大细胞增多症IgE轴在蠕虫感染中的功能意义尚不清楚，并表明在某些蠕虫感染中，TH 2细胞细胞因子可能有助于宿主保护，而在其他情况下，它们可能促进寄生虫存活。
The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.