Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia
Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia
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DOI：
10.1016/j.mayocp.2017.02.014
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发表时间：
2017-04-01
影响因子：
8.9
通讯作者：
Lee, Kendall H.
中科院分区：
文献类型：
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作者：
Grahn, Peter J.;Lavrov, Igor A.;Lee, Kendall H.
我们报告了一例慢性创伤性截瘫病例，其中腰骶脊髓的硬膜外电刺激（EES）能够（1）对任务特异性肌肉活动的意志控制，（2）对节律性肌肉活动的意志控制，以在侧卧时产生阶梯式运动，（3）独立站立，以及（4）在体重部分支撑的垂直位置时，自主控制阶梯式运动和节律性肌肉活动。这是 EES 的应用首次在 EES 治疗的前 2 周（总共 8 次刺激疗程）内使同一患者能够完成所有这些任务。 (C) 2017 梅奥医学教育与研究基金会
We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy. (C) 2017 Mayo Foundation for Medical Education and Research