Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids.
Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids.
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血管内皮生长因子受体2在氧化磷脂激活主动脉内皮细胞中发挥作用。
DOI：
10.1161/01.atv.0000252842.57585.df
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Berliner,JudithA
中科院分区：
文献类型：
--
作者：
Zimman,Alejandro;Mouillesseaux,KevinP;Le,Thang;Gharavi,NimaM;Ryvkin,Ann;Graeber,ThomasG;Chen,TomT;Watson,AndrewD;Berliner,JudithA
Objective—Previous studies have shown that oxidized products of PAPC (Ox-PAPC) regulate cell transcription of interleukin-8, LDL receptor, and tissue factor. This upregulation takes place in part through the activation of sterol regulatory element-binding protein (SREBP) and Erk 1/2. The present studies identify vascular endothelial growth factor receptor 2 (VEGFR2) as a major regulator in the activation of SREBP and Erk 1/2 in endothelial cells activated by Ox-PAPC.Methods and Results—Ox-PAPC induced the phosphorylation of VEGFR2 at Tyr1175in human aortic endothelial cells. Inhibitors and siRNA for VEGFR2 decreased the transcription of interleukin-8, LDL receptor, and tissue factor in response to Ox-PAPC and the activation of SREBP and Erk 1/2, which mediate this transcription. We provide evidence that the activation of VEGFR2 is rapid, sustained, and c-Src–dependent.Conclusions—These data point to a major role of VEGFR2 in endothelial regulation by oxidized phospholipids which accumulate in atherosclerotic lesions and apoptotic cells.
