Guillain-Barre syndrome after influenza vaccination in the United States, a report from the CDC/FDA vaccine adverse event reporting system (1990-2009).
Guillain-Barre syndrome after influenza vaccination in the United States, a report from the CDC/FDA vaccine adverse event reporting system (1990-2009).
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DOI：
10.1097/cnd.0b013e31824db14e
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发表时间：
2012-12-01
影响因子：
--
通讯作者：
Qureshi, Adnan I
中科院分区：
文献类型：
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作者：
Souayah, Nizar;Yacoub, Hussam A;Qureshi, Adnan I
目的：确定美国接种流感疫苗后格林-巴利综合征（GBS）的发病率，并提供有关这些事件的特征和时间分布的进一步信息。方法：数据来自疫苗不良事件报告系统，并补充了1990年至2009年信息自由法案下生物制品和研究中心的数据。结果：1990年至2009年期间，美国报告了802例流感疫苗接种后的GBS病例（平均年龄54.72 ± 18.4岁）。在有可用数据的802例接种疫苗的患者中，624例（77.8%）在6周内发生GBS，78例（9.7%）在6周后发生GBS，而其余100例患者（13%）的这些数据不可用。流感疫苗接种后GBS的报告率在一般人群的预期范围内，约为每百万次接种0.46例。接种疫苗后的第一个6周内的GBS的非高斯分布，注意到，在第二周发生的发病率峰值。结论：流感疫苗后GBS的发病率是类似的特发性GBS在一般人群中的发病率。尽管接种后GBS的非正态分布表明，某些病例可能是由接种疫苗引发的，但流感病毒感染并发症的风险更大，使接种疫苗成为预防感染的一线策略，并支持当前的疫苗接种指南。
OBJECTIVES: To determine the rate of Guillain-Barre syndrome (GBS) after administration of influenza vaccine in the United States and to provide further information about the characteristics and temporal profile of these incidents.METHODS: Data were acquired from the Vaccine Adverse Event Reporting System, supplemented by data from the Center for Biologics and Research under the Freedom of Information Act between 1990 and 2009.RESULTS: There were 802 cases (mean age, 54.72 ± 18.4 years) of GBS reported after influenza vaccination in the United States between 1990 and 2009. Among the 802 vaccinated patients with available data, 624 (77.8%) developed GBS within 6 weeks and 78 (9.7%) after 6 weeks, whereas these data were unavailable for the remaining 100 patients (13%). The reporting rate of post-influenza vaccine GBS was within the range expected in the general population or approximately 0.46 cases per million vaccinations. A non-Gaussian distribution of GBS within the first 6 weeks post-vaccination was noted, given that the peak incidence occurred in the second week.CONCLUSIONS: The incidence of post-influenza vaccine GBS is similar to the incidence of idiopathic GBS in the general population. Although the nonnormal distribution of post-vaccination GBS suggests that some cases may be triggered by vaccination, the greater risk of complications from influenza virus infections makes vaccination the first-line strategy for infection prevention and support the current guidelines on vaccination.