Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition
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DOI：
10.1128/iai.73.8.5249-5251.2005
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发表时间：
2005-08-01
影响因子：
3.1
通讯作者：
Phillips, RS
中科院分区：
文献类型：
--
作者：
Clark, CJ;Mackay, GM;Phillips, RS
感染伯氏疟原虫ANKA的C57 BL/6 J小鼠发生神经功能障碍，并在感染后7天内死亡。我们发现用犬尿氨酸-3-羟化酶抑制剂治疗感染的小鼠可以防止它们出现神经系统症状，并将它们的寿命延长三倍，直到严重贫血发生。
C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hvdroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.