Structure and dynamics of core/periphery networks
Structure and dynamics of core/periphery networks
复制标题
核心/外围网络的结构和动态
DOI：
10.1093/comnet/cnt016
复制
发表时间：
2013-12-01
影响因子：
2.1
通讯作者：
Uzzi, Brian
中科院分区：
文献类型：
--
作者：
Csermely, Peter;London, Andras;Uzzi, Brian
最近的研究发现了重要的核心/外围网络结构，其特征在于网络节点（无论是蛋白质、细胞、物种还是人类）之间复杂的合作和竞争相互作用。更好地表征核心/外围网络的结构、动态和功能是我们理解细胞功能、物种适应、社会和市场变化的关键一步。在这里，我们总结了当前关于“传统”核心/外围网络、富俱乐部网络、嵌套网络、领结网络和洋葱网络的结构和动态的知识。将核心/外围结构与网络模块进行比较，我们区分全局核心和局部核心。核心/外围网络组织处于多种极端性质的中间，例如随机/凝聚结构、派系/星型结构、网络对称/不对称、网络同配/异配、以及网络层次/反层次。这些高复杂性的特性加上核心路径的大简并性确保了合作并提供了网络流重新引导的多种选项，极大地有助于复杂系统的高鲁棒性。核心过程能够对各种刺激做出协调反应，减少噪音，并缓慢进化。网络核心的整合功能是多种复杂生物和组织发展的重要一步。除了这些重要特征和几十年来的研究兴趣之外，核心/外围网络的研究仍然有许多未探索的领域。
Recent studies uncovered important core/periphery network structures characterizing complex sets of cooperative and competitive interactions between network nodes, be they proteins, cells, species or humans. Better characterization of the structure, dynamics and function of core/periphery networks is a key step of our understanding cellular functions, species adaptation, social and market changes. Here we summarize the current knowledge of the structure and dynamics of "traditional" core/periphery networks, rich-clubs, nested, bow-tie and onion networks. Comparing core/periphery structures with network modules, we discriminate between global and local cores. The core/periphery network organization lies in the middle of several extreme properties, such as random/condensed structures, clique/star configurations, network symmetry/asymmetry, network assortativity/disassortativity, as well as network hierarchy/anti-hierarchy. These properties of high complexity together with the large degeneracy of core pathways ensuring cooperation and providing multiple options of network flow re-channelling greatly contribute to the high robustness of complex systems. Core processes enable a coordinated response to various stimuli, decrease noise, and evolve slowly. The integrative function of network cores is an important step in the development of a large variety of complex organisms and organizations. In addition to these important features and several decades of research interest, studies on core/periphery networks still have a number of unexplored areas.