Short and Long Term Measures of Anxiety Exhibit Opposite Results
Short and Long Term Measures of Anxiety Exhibit Opposite Results
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DOI：
10.1371/journal.pone.0048414
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发表时间：
2012-10-31
期刊：
影响因子：
3.7
通讯作者：
Golani, Ilan
中科院分区：
文献类型：
--
作者：
Fonio, Ehud;Benjamini, Yoav;Golani, Ilan
包括广泛性焦虑症在内的人类中枢神经系统疾病的动物模型对于研究大脑-行为界面和药物开发至关重要;然而，这些模型未能产生新的见解和有效的药物。通过将测试持续时间增加100倍，将竞技场的规模扩大10倍，并将普通动物模型的行为与野生小鼠的行为进行比较，我们提出了这样一个问题：慢性焦虑可能在错误的时间、错误的持续时间和错误的动物中被测量。此外，小鼠以短暂适应新环境的时间段（习惯期）和反映小鼠各自特征的长时间段开始实验会话。使用常见的焦虑测量方法显示，小鼠在这些时期表现出相反的结果，这表明慢性焦虑应该在适应后时期进行测量。我们推荐用于测量瞬变期的工具，并提供表征后习惯期的建议。
Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that of wild mice, we raise concerns that chronic anxiety might have been measured at the wrong time, for the wrong duration, and in the wrong animal. Furthermore, the mice start the experimental session with a short period of transient adaptation to the novel environment (habituation period) and a long period reflecting the respective trait of the mice. Using common measures of anxiety reveals that mice exhibit opposite results during these periods suggesting that chronic anxiety should be measured during the post-habituation period. We recommend tools for measuring the transient period, and provide suggestions for characterizing the post habituation period.