Maternal and fetal outcomes of 72 pregnancies in Argentine patients with systemic lupus erythematosus (SLE)
Maternal and fetal outcomes of 72 pregnancies in Argentine patients with systemic lupus erythematosus (SLE)
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DOI：
10.1007/s10067-007-0649-3
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发表时间：
2008-01-01
影响因子：
3.4
通讯作者：
Nasswetter, Gustavo G.
中科院分区：
文献类型：
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作者：
Cavallasca, Javier A.;Laborde, Hugo A.;Nasswetter, Gustavo G.
本研究旨在分析系统性红斑狼疮（SLE）妊娠患者的母胎结局，以及SLE加重对妊娠的影响。回顾性分析了1986年1月至2004年2月在圣马丁临床医院治疗的61例SLE患者72例妊娠。患者年龄28.1±6.2岁（平均±标准差[SD]）。SLE平均病程为4.5 +/- 3.2年（6个月-10年）。没有患者在妊娠期间获得这种疾病。4例（5.5%）患者在妊娠初期有活动性疾病的迹象。16例患者，占20例妊娠，有狼疮性肾炎病史。9例患者符合继发性抗磷脂综合征标准，13例妊娠。妊娠期有14次加重（19.4%），多数为轻度发作。最常见的产科并发症是15例妊娠高血压（20.8%）和8例妊娠先兆子痫（11%）。46%的怀孕以早产告终。62例活产（1例双胞胎，占85%），6例死产（8%），5例自然流产（7%）。39%的新生儿出生体重过低。一个跨学科团队对阿根廷SLE患者进行了充分的妊娠随访和分娩护理，没有孕前准备，结果与世界参考中心的结果相似。
The purpose of the following study was to analyze maternal and fetal outcomes in pregnant patients with systemic lupus erythematosus (SLE) and the influence of SLE exacerbations on those pregnancies. Seventy-two pregnancies in 61 SLE patients treated between January 1986 and February 2004 in Hospital de Clinicas "Jose de San Martin" were reviewed retrospectively. Patient age was 28.1 +/- 6.2 years (mean +/- standard deviation [SD]). Mean SLE duration was 4.5 +/- 3.2 years (range 6 months-10 years). No patient acquired the disorder during gestation. Four (5.5%) patients had signs of active disease at the beginning of her pregnancy. Sixteen patients, accounting for 20 pregnancies, had a history of lupus nephritis. Nine patients met secondary antiphospholipid syndrome criteria and had 13 pregnancies. There were 14 exacerbations of the disease during pregnancy (19.4%), with most flares being mild. The most common obstetric complications were gestational hypertension in 15 pregnancies (20.8%) and preeclampsia in 8 pregnancies (11%). Forty-six percent of pregnancies ended in preterm deliveries. There were 62 live births (1 twin birth; 85%), 6 stillbirths (8%), and 5 spontaneous abortions (7%). Thirty-nine percent of newborns had low birth weight. Adequate pregnancy follow-up and delivery care by an interdisciplinary team in Argentine SLE patients with no pre-gestational preparation resulted in maternal and fetal outcomes similar to those seen in world reference centers.