Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia
Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia
复制标题
DOI：
10.1038/sj.mp.4001321
复制
发表时间：
2003-01-01
影响因子：
11
通讯作者：
Tsuang, MT
中科院分区：
文献类型：
--
作者：
Glatt, SJ;Faraone, SV;Tsuang, MT
多巴胺受体D2亚型与精神分裂症的发病机制有广泛的关系。支持D2受体基因（DRD2） Cys311Ser多态性与精神分裂症之间关联的早期证据随后被反驳，并最终被驳回。从所有24项已发表的病例对照研究中，我们计算了这种关联的汇总估计。Cys等位基因的合并优势比为1.3，极显著（P=0.007）。每项研究得出的比值比与样本的种族或性别组成或对照组的年龄无关。没有证据表明任何研究存在发表偏倚或过度影响。尽管需要更多基于家庭的研究来证实这种关系，但我们的研究结果提供了强有力的证据，证明DRD2影响精神分裂症的易感性。
The D2 subtype of dopamine receptor has been widely implicated in the pathogenesis of schizophrenia. Early evidence supporting an association between the Cys311Ser polymorphism of the D2 receptor gene (DRD2) and schizophrenia was subsequently refuted and, eventually, dismissed. From all 24 published case-control studies, we calculated a pooled estimate of this association. The pooled odds ratio was 1.3 for the Cys allele, which was highly significant (P=0.007). The odds ratio derived from each study was unrelated to the ethnicity or gender composition of the sample, or the age of the control group. There was no evidence of publication bias or excessive influence attributable to any given study. Although more family-based studies are needed to confirm this relation, our results provide strong evidence that DRD2 influences susceptibility to schizophrenia.