FORMATION OF THE TC=N MULTIPLE BOND FROM THE REACTION OF AMMONIUM PERTECHNETATE WITH S-METHYL DITHIOCARBAZATE AND ITS APPLICATION TO THE PREPARATION OF TC-99M RADIOPHARMACEUTICALS
FORMATION OF THE TC=N MULTIPLE BOND FROM THE REACTION OF AMMONIUM PERTECHNETATE WITH S-METHYL DITHIOCARBAZATE AND ITS APPLICATION TO THE PREPARATION OF TC-99M RADIOPHARMACEUTICALS
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DOI：
10.1039/dt9900003729
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发表时间：
1990-12-01
期刊：
影响因子：
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通讯作者：
PASQUALINI, R
中科院分区：
文献类型：
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作者：
DUATTI, A;MARCHI, A;PASQUALINI, R
在 HCl 和三苯基膦存在下，高锝酸与二硫代肼基甲酸的 S-甲酯 H2N-NR-C(=S)SCH3（R = H 或 CH3）反应，以高产率得到锝(v)氮化物络合物 [TcNCl2(PPh3)2]。 R1(R2) C = N-NR3-C( = S)SCH3 类型的 S-二硫代氨基甲酸甲酯衍生物，其中 R1 = 0-C6H4OH、C6H5 或 CH3，R2 = H 或 CH3，R3 = H 或 CH3，作为 N3- 基团的来源，产生各种含有 Tc = N 多重键的锝配合物。 这些反应同样适用于在核医学的非载体添加水平上制备含有 Tc = N 基团的 Technetium-99m 放射性药物。
The reaction of pertechnetate with the S-methyl ester of dithiocarbazic acid, H2N-NR-C(=S)SCH3 (R = H or CH3), in the presence of HCl and triphenylphosphine, affords the technetium(v) nitrido complex [TcNCl2(PPh3)2] in high yield. Derivatives of S-methyl dithiocarbazate of the type R1(R2) C = N-NR3-C( = S)SCH3, where R1 = 0-C6H4OH, C6H5, or CH3, R2 = H or CH3, and R3 = H or CH3, behave as sources of N3- groups, giving rise to a variety of technetium complexes containing the Tc = N multiple bond. These reactions apply equally well to the preparation of technetium-99m radiopharmaceuticals containing the Tc = N group, at the non-carrier-added level of nuclear medicine.