Prenatal exposure to chemical carcinogens and its effect on subsequent generations.
Prenatal exposure to chemical carcinogens and its effect on subsequent generations.
复制标题
产前接触化学致癌物及其对后代的影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
L. Tomatis
中科院分区：
文献类型：
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作者：
L. Tomatis
怀孕的动物暴露在化学致癌物下会导致后代发生肿瘤，这是有充分证据的。已经积累了至少38种属于不同化学类别的化学品的证据。在实验证据之后，在人类中观察到怀孕期间服用己烯雌酚的妇女的女儿患癌症的风险增加。越来越多的实验证据表明，孕期暴露可能会增加一代以上未经治疗的后代的肿瘤发病率。在患有DMBA的小鼠和患有MNU和ENU的大鼠上进行的研究表明，怀孕期间接触致癌物会导致第一代动物肿瘤的高发病率，并导致第二代和第三代未经治疗的动物特定部位肿瘤发生率增加。
That exposure of pregnant animals to chemical carcinogens results in the occurrence of tumors in the progeny is well documented. Evidence has been accumulated on at least 38 chemicals pertaining to different chemical groups. The experimental evidence was followed by observations in humans regarding the increased risk of cancer in daughters of women who received stilbestrol during pregnancy. Additional experimental evidence is accumulating on the possibility that exposure during pregnancy results in an increased incidence of tumors for more than one generation of untreated descendants. Studies done on mice with DMBA and on rats with MNU and ENU showed that exposure to the carcinogens during pregnancy resulted in a high incidence of tumors in animals of the first generation and in an increased incidence of tumors at specific sites in untreated animals of the second and third generations.