Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia.
Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia.
复制标题
分泌性白细胞蛋白酶抑制剂和支气管肺发育不良中的肺部炎症。
DOI：
10.1016/s0022-3476(94)70209-8
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Murphy,S
中科院分区：
文献类型：
--
作者：
Watterberg,KL;Carmichael,DF;Gerdes,JS;Werner,S;Backstrom,C;Murphy,S
目的：探讨分泌性白细胞蛋白酶抑制剂（SLPI）的浓度在气管灌洗液中的新生儿与气管插管的地方在第一个月的生活，并评估SLPI的关系，中性粒细胞计数和弹性蛋白酶活性的患者中，支气管肺发育不良（BPD）的发展与那些在谁doesn 't.Design：一个前瞻性的，初始队列研究。41例患者存活至28天; 24例患者发生BPD，但17例患者未发生BPD。主要结果指标：在第1、2、4、7、14、21和28天进行气管灌洗，并分析中性粒细胞、弹性蛋白酶活性和SLPI。结果进行了纵向评价28天，并进行了比较BPD和无BPD组在第一week.Results：SLPI浓度增加显着为所有患者在研究期间。在第一周，SLPI浓度之间的BPD和无BPD组相似;中性粒细胞计数和弹性蛋白酶活性较高的BPD group.Conclusions：BPD患者最终开发的早期证据增加肺部炎症和一个显着不太有利的蛋白酶-抗蛋白酶平衡。如果弹性蛋白酶诱导的损伤有助于BPD的发展，早期用重组SLPI治疗可能是有益的，增加抗弹性蛋白酶能力的上皮衬里液。（J PEDIATR 1994;125：264-9）
Objective:To investigate secretory leukocyte protease inhibitor (SLPI) concentrations in tracheal lavage fluids of neonates with an endotracheal tube in place during the first month of life, and to evaluate the relationship of SLPI to neutrophil counts and elastase activity in patients in whom bronchopulmonary dysplasia (BPD) developed versus those in whom it did not.Design:A prospective, inception cohort study.Setting:University children's hospital neonatal intensive care unit.Patients:Fifty-three neonates who weighed <2000 gm at birth, and who had an endotracheal tube in place, were enrolled. Forty-one patients survived to 28 days; BPD developed in 24 but not in 17 patients.Main outcome measures:Tracheal lavage was performed on days 1, 2, 4, 7, 14, 21, and 28, and analyzed for neutrophils, elastase activity, and SLPI. Results were evaluated longitudinally for 28 days, and were compared between BPD and no-BPD groups during the first week.Results:SLPI concentrations increased significantly for all patients during the study period. During the first week, SLPI concentrations were similar between BPD and no-BPD groups; neutrophil counts and elastase activity were higher in the BPD group.Conclusions:Patients in whom BPD ultimately developed had early evidence of increased pulmonary inflammation and a significantly less favorable protease-antiprotease balance. If elastase-induced injury contributes to the development of BPD, early therapy with recombinant SLPI might be beneficial by increasing the antielastase capacity of epithelial lining fluid. (J PEDIATR1994;125:264-9)