Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications
Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications
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DOI：
10.1007/s00125-004-1336-4
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发表时间：
2004-03-01
期刊：
影响因子：
8.2
通讯作者：
Halban, PA
中科院分区：
文献类型：
--
作者：
Donath, MY;Halban, PA
越来越多的证据表明，功能性β细胞质量减少是1型和2型糖尿病的标志。这是两种情况下绝对或相对胰岛素不足的基础。在这篇辩论中，我们考虑了导致β细胞死亡和功能受损的可能机制，以及它们对糖尿病胰岛素不足的相对贡献。β细胞凋亡和受损的增殖，随之而来的高血糖症是一个途径，可以在所有形式的糖尿病。自身免疫和其他途径的β细胞死亡也被考虑在内。认识到功能性β细胞群减少及其在糖尿病状态中重叠的多因素病因，使我们提出了糖尿病的统一分类。
Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or relative insulin insufficiency in both conditions. In this For Debate, we consider the possible mechanisms responsible for beta-cell death and impaired function and their relative contribution to insulin insufficiency in diabetes. Beta-cell apoptosis and impaired proliferation consequent to hyperglycaemia is one pathway that could be operating in all forms of diabetes. Autoimmunity and other routes to beta-cell death are also considered. Recognition of decreased functional beta-cell mass and its overlapping multifactorial aetiology in diabetic states, leads us to propose a unifying classification of diabetes.