FEAR CONDITIONING ENHANCES SHORT-LATENCY AUDITORY RESPONSES OF LATERAL AMYGDALA NEURONS - PARALLEL RECORDINGS IN THE FREELY BEHAVING RAT
FEAR CONDITIONING ENHANCES SHORT-LATENCY AUDITORY RESPONSES OF LATERAL AMYGDALA NEURONS - PARALLEL RECORDINGS IN THE FREELY BEHAVING RAT
复制标题
DOI：
10.1016/0896-6273(95)90092-6
复制
发表时间：
1995-11-01
期刊：
影响因子：
16.2
通讯作者：
LEDOUX, JE
中科院分区：
文献类型：
--
作者：
QUIRK, GJ;REPA, JC;LEDOUX, JE
杏仁核外侧核（LA）是杏仁核中第一个可能发生恐惧条件反射的可塑性的部位。在恐惧条件反射试验中，我们同时记录了自由运动大鼠的多个LA神经元，其中音调与足部电击配对。条件反射显著增加了音调引起的反应的幅度（通常在最初的几次试验中），将无反应的细胞转化为音调反应的细胞，并改变了LA神经元之间的功能偶联。条件反射对音调诱发反应的最短潜伏期（小于15毫秒）的影响最大，这与从听觉丘脑到LA的直接投射是回路中的一个重要环节的假设相一致，通过该回路，在条件恐惧刺激的存在下控制快速行为反应。
The lateral nucleus of the amygdala (LA) is the first site in the amygdala where the plasticity underlying fear conditioning could occur. We simultaneously recorded from multiple LA neurons in freely moving rats during fear conditioning trials in which tones were paired with foot shocks. Conditioning significantly increased the magnitude of tone-elicited responses (often within the first several trials), converted unresponsive cells into tone-responsive ones, and altered functional couplings between LA neurons. The effects of conditioning were greatest on the shortest latency (less than 15 ms) components of the tone-elicited responses, consistent with the hypothesis that direct projections from the auditory thalamus to LA are an important link in the circuitry through which rapid behavioral responses are controlled in the presence of conditioned fear stimuli.