Fatal Measles Virus Infection Prevented by Brain-Penetrant Fusion Inhibitors
Fatal Measles Virus Infection Prevented by Brain-Penetrant Fusion Inhibitors
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DOI：
10.1128/jvi.02436-13
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发表时间：
2013-12-01
影响因子：
5.4
通讯作者：
Porotto, Matteo
中科院分区：
文献类型：
--
作者：
Welsch, Jeremy C.;Talekar, Aparna;Porotto, Matteo
麻疹病毒（MV）感染引起急性儿童疾病，可包括中枢神经系统感染，很少进展为严重的神经系统疾病，对此没有特异性治疗。我们产生了MV进入和传播以及MV诱导的细胞融合的有效抗病毒肽抑制剂。MV特异性肽的二聚体衍生自MV融合蛋白的C-末端七肽重复区，与胆固醇缀合，有效地保护SLAM转基因小鼠免受致命的MV感染。融合抑制剂有望预防未接种疫苗和免疫功能低下人群的MV感染，以及治疗麻疹严重神经系统并发症的潜力。
Measles virus (MV) infection causes an acute childhood disease that can include infection of the central nervous system and can rarely progress to severe neurological disease for which there is no specific treatment. We generated potent antiviral peptide inhibitors of MV entry and spreading and MV-induced cell fusion. Dimers of MV-specific peptides derived from the C-terminal heptad repeat region of the MV fusion protein, conjugated to cholesterol, efficiently protect SLAM transgenic mice from fatal MV infection. Fusion inhibitors hold promise for the prophylaxis of MV infection in unvaccinated and immunocompromised people, as well as potential for the treatment of grave neurological complications of measles.