Estimation of the total concentration of perfluoroalkyl acids (PFAA) in human serum: Data from NHANES 2005-2012
Estimation of the total concentration of perfluoroalkyl acids (PFAA) in human serum: Data from NHANES 2005-2012
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DOI：
10.1016/j.chemosphere.2015.04.104
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发表时间：
2015-09-01
期刊：
影响因子：
8.8
通讯作者：
Jain, Ram B.
中科院分区：
文献类型：
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作者：
Jain, Ram B.
虽然已在实验室检测和测量了全氟辛酸盐（PFOA）和全氟辛烷磺酸盐（PFOS）等选定的全氟烷基酸/物质（PFAA），但尚未开发出估算血清中全氟烷基酸（Sigma PFAA）总浓度的方法。由于与PFAA相关的健康问题，由于每个实验室无法测量每一种PFAA，以及由于没有足够灵敏的设备能够检测非常少量的某些PFAA，因此了解Sigma PFAA是有意义的。我们使用了2005-2012年国家健康和营养调查的数据，开发了回归模型，仅使用PFOA和PFOS的水平来估计Sigma PFAA。2005-2008年的数据用于建立回归模型，2009-2012年的数据用于评价所建立模型的准确性。超过63%的评价数据的观察值被发现在预测值的10%以内。这样开发的模型可以使用的年龄，性别和浓度的全氟辛酸和全氟辛烷磺酸的知识。虽然用于开发模型的数据是在美国生成的，该模型可用于估计在北美和欧洲以及可能在世界其他地方收集的数据的西格玛PFAA。(C)2015爱思唯尔有限公司版权所有。
While selected perfluoroalkyl acids/substances (PFAAs) like perfluorooctanoate (PFOA) and perfluorooctane stilfonate (PFOS) have been detected and measured in laboratory, a method to estimate the total concentration of PFAAs (Sigma PFAA) in serum has not been developed. Because of the health concerns associated with PFAAs and because of the inability of every laboratory to measure every PFAA as well as because of the non-availability of sensitive enough equipment to be able to detect very small amounts of certain PFAAs, it is of interest to know Sigma PFAA. We used data from the National Health and Nutrition Examination Survey for the years 2005-2012 to develop regression models to estimate Sigma PFAA by using the levels of PFOA and PFOS only. While data for 2005-2008 were used to develop regression models, data for 2009-2012 were used to evaluate the accuracy of the developed models. Over 63% of observed values for evaluation data were found to be within 10% of the predicted values. The model so developed can be used with just the knowledge of the age, gender, and concentrations of PFOA and PFOS. While the data used to develop the model were generated in U.S., the model can be used to estimate Sigma PFAA for data collected in North America and Europe and probably elsewhere in the world. (C) 2015 Elsevier Ltd. All rights reserved.