Ylangene-Type and Nardosinane-Type Sesquiterpenoids from the Soft Corals Lemnalia flava and Paralemnalia thyrsoides
Ylangene-Type and Nardosinane-Type Sesquiterpenoids from the Soft Corals Lemnalia flava and Paralemnalia thyrsoides
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DOI：
10.1248/cpb.58.381
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发表时间：
2010-03-01
影响因子：
1.7
通讯作者：
Duh, Chang-Yih
中科院分区：
文献类型：
--
作者：
Cheng, Shi-Yie;Lin, En-Hung;Duh, Chang-Yih
从台湾软珊瑚Lemnalia flava中分离得到一种新的依兰烯型倍半萜，（1 S，2S，4 R，6S，7 R，8 S）-4 α-甲酰氧基-β-依兰烯（1），沿着两种已知的倍半萜，lemnalol（2）和isolemnalol（3）。三个新的强心烷型倍半萜，。命名为降胆固醇。J-L（4-6）和已知的活倍半萜（7-11）是从其他软珊瑚Paralemnalia thyrsoides中分离得到的。通过广泛的光谱分析和化学方法阐明了代谢产物1和4-6的结构。此外，体外评价了代谢产物1-7和11的抗炎活性。
Chemical investigations of the Formosan soft coral Lemnalia flava have obtained a new ylangene-type sesquiterpenoid, (1S,2S,4R,6S,7R,8S)-4 alpha-formyloxy-beta-ylangene (1), along with two known sesquiterpenoids, lemnalol (2) and isolemnalol (3). Three new nardosinane-type sesquiterpenoids,. designated as paraleninolins. J-L (4-6), and live known sesquiterpenoids (7-11), were isolated from the other soft coral Paralemnalia thyrsoides. The structures of metabolites 1 and 4-6 were elucidated through extensive spectroscopic analysis and chemical methods. Moreover, the anti-inflammatory activity of metabolites 1-7 and 11 was evaluated ill vitro.