The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms.
The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms.
复制标题
精神分裂症患者对芬氟拉明的催乳素反应与阴性症状相关。
DOI：
10.1016/s0920-9964(99)00014-6
复制
发表时间：
1999
影响因子：
4.5
通讯作者：
Pandey,GN
中科院分区：
文献类型：
--
作者：
Sharma,RP;Singh,V;Janicak,PG;Javaid,JI;Pandey,GN
我们在一项对照血管导管研究中，通过给予口服dl-芬氟拉明（芬氟拉明）的挑战剂量，检查了无药物住院患者[精神分裂症（n=28）和情感障碍（n=7）]的多巴胺能系统。其中17名患者除了接受芬氟拉明外，还被随机分配到安慰剂组。通过重复测量ANOVA以及曲线下面积（AUC）检查血清催乳素和皮质醇变化所反映的对芬氟拉明的反应。催乳素反应，而不是皮质醇反应，与阴性症状的措施显着相关。
We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms.