A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC
A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC
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DOI：
10.1016/s0969-8051(01)00226-8
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发表时间：
2001-08-01
影响因子：
3.1
通讯作者：
Jewett, DM
中科院分区：
文献类型：
--
作者：
Jewett, DM
制备[C-11]卡芬太尼，无需通过HPLC纯化。使前体羧酸盐的四丁基铵盐与[C-11]三氟甲磺酸甲酯在DMSO中反应。将所得的[C-11]卡芬太尼捕获在Empore萃取盘上并洗涤以除去前体和大多数放射性污染物。用少量乙醇洗脱产物，与水混合，并通过含有纤维阴离子交换剂的小柱，以除去残留的放射性污染物。(C)2001 Elsevier Science Inc. All rights reserved.
[C-11]Carfentanil was prepared without the need for purification by HPLC. The tetrabutylammonium salt of the precursor carboxylate was reacted with [C-11]methyl triflate in DMSO. The resulting [C-11]carfentanil was trapped on an Empore extraction disk and washed to remove precursor and most radioactive contaminants. The product was eluted by a small volume of ethanol, mixed with water and passed through a small column containing fibrous anion exchanger to remove remaining radioactive contaminants. (C) 2001 Elsevier Science Inc. All rights reserved.