Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants
Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants
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DOI：
10.1024/0300-9831.72.4.237
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发表时间：
2002-07-01
影响因子：
2.3
通讯作者：
Aoki, K
中科院分区：
文献类型：
--
作者：
Ito, Y;Suzuki, K;Aoki, K
本研究的目的是调查日本居民的死亡率和血清抗氧化剂水平之间是否存在关系。参加全面健康检查的随访对象包括日本北海道农村地区的2444名居民（949名男性和1495名女性）。1991年至2000年12月，146名受试者（94名男性和52名女性）死亡，其中76人死于癌症（48名男性和28名女性）。在进入研究时采集空腹血清样品，并通过高效液相色谱法（HPLC）分别测量β-和α-胡萝卜素、番茄红素、β-隐黄素、玉米黄质/叶黄素、生育酚和视黄醇的血清水平。使用考克斯比例风险模型进行统计分析。血清中番茄红素、β-胡萝卜素、玉米黄质/叶黄素和总类胡萝卜素水平高的组与血清中番茄红素、β-胡萝卜素、玉米黄质/叶黄素和总类胡萝卜素水平低的组相比，经年龄和性别调整后的风险比为0.36（95% C.I：0.19-0.69），0.53（0.29-0.95）、0.73（0.43-1.25）和0.52（0.30-0.92），全因癌分别为0.44（95% C.I：0.28-0.69）、0.59（0.39-0.90）、0.61（0.40-0.93）和0.50（0.33-0.76）。在调整性别、年龄、吸烟习惯、饮酒量、血清总胆固醇水平和谷丙转氨酶（GPT）活性后，发现了类似的结果。此外，在排除了随访前三年内的死亡率后，在调整性别、年龄和血清总胆固醇、α-生育酚和视黄醇水平后，血清番茄红素、总胡萝卜素和总类胡萝卜素水平高的受试者的风险比与所有原因和所有部位癌症的后续死亡率显著负相关。这些结果表明，高血清水平的抗氧化剂，如番茄红素，β-胡萝卜素和玉米黄质/叶黄素，在预防癌症和所有原因导致的死亡中发挥作用。然而，高血清生育酚和视黄醇水平并没有表现出明确的相关性，无论是低死亡率的所有原因或癌症的所有网站。
The purpose of this study was to investigate whether a relationship exists between mortality rates and serum antioxidant levels among Japanese inhabitants. The follow-up subjects, who participated in comprehensive health examinations, consisted of 2444 inhabitants (949 males and 1495 females) of a rural area in Hokkaido, Japan. Between 1991 and December 2000, 146 subjects (94 males and 52 females) died, with cancer accounting for 76 of these deaths (48 males and 28 females). Serum samples at fasting were collected at entry into the study, and serum levels of beta- and alpha-carotenes, lycopene, beta-cryptoxanthin, canthaxanthin, zeaxanthin/lutein, tocopherols, and retinol were measured separately by high-performance liquid chromatography (HPLC). The statistical analyses were conducted using the Cox proportional hazard model. Age- and gender-adjusted hazard ratios of the groups with high serum levels of lycopene, beta-carotene, zeaxanthin/lutein, and total carotenoids compared to those with low serum levels were 0.36 (95% C.I: 0.19-0.69), 0.53 (0.29-0.95), 0.73 (0.43-1.25), and 0.52 (0.30-0.92) for cancers of all sites, and 0.44 (95% C.I: 0.28-0.69), 0.59 (0.39-0.90), 0.61 (0.40-0.93), and 0.50 (0.33-0.76) for all causes, respectively. Similar results were found after adjusting for gender, age, smoking habits, alcohol consumption, and serum levels of total cholesterol and glutamic pyruvic transaminase (GPT) activity. Moreover, after excluding mortality within the first three years of follow-up, the hazard ratios of subjects with high serum levels of lycopene, total carotenes, and total carotenoids were significantly and inversely associated with subsequent mortality from all causes and cancers of all sites after adjusting for gender, age, and serum levels of total cholesterol, alpha-tocopherol, and retinol. These results suggest that high serum levels of antioxidants, such as lycopene, beta-carotene and zeaxanthin/lutein, play roles in preventing death from cancer and from all causes. However, high serum levels of tocopherols and retinol did not demonstrate clear associations with either low mortality rates from all causes or cancer of all sites.