Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
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DOI：
10.3390/ijms20225549
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发表时间：
2019-11
影响因子：
5.6
通讯作者：
Y. Ueno;N. Miyamoto;K. Yamashiro;R. Tanaka;N. Hattori
中科院分区：
文献类型：
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作者：
Y. Ueno;N. Miyamoto;K. Yamashiro;R. Tanaka;N. Hattori
中风是世界范围内死亡和残疾的主要原因。N-3多不饱和脂肪酸(PUFA)包括二十碳五烯酸和二十二碳六烯酸，具有强大的抗炎作用，减少血小板聚集，逆转动脉粥样硬化斑块。自从发现饮食中含有大量海洋n-3多不饱和脂肪酸的格陵兰爱斯基摩人的冠心病发病率低于西方人群以来，人们进行了大量的流行病学研究，以探索饮食中鱼类和n-3多不饱和脂肪酸与心血管疾病的关系，并进行了大规模的临床试验，以确定n-3多不饱和脂肪酸治疗的益处。在大多数这些研究中，中风的发病率和死亡率也主要作为次要终点进行评估。因此，本文对流行病学研究中膳食摄入n-3多不饱和脂肪酸与卒中的关系以及临床试验中n-3多不饱和脂肪酸的治疗效果进行了系统的文献综述。此外，还对最近的实验研究进行了综述，以探讨n-3多不饱和脂肪酸对卒中后神经保护作用的分子机制。
Stroke is a major leading cause of death and disability worldwide. N-3 polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid and docosahexaenoic acid have potent anti-inflammatory effects, reduce platelet aggregation, and regress atherosclerotic plaques. Since the discovery that the Greenland Eskimo population, whose diet is high in marine n-3 PUFAs, have a lower incidence of coronary heart disease than Western populations, numerous epidemiological studies to explore the associations of dietary intakes of fish and n-3 PUFAs with cardiovascular diseases, and large-scale clinical trials to identify the benefits of treatment with n-3 PUFAs have been conducted. In most of these studies the incidence and mortality of stroke were also evaluated mainly as secondary endpoints. Thus, a systematic literature review regarding the association of dietary intake of n-3 PUFAs with stroke in the epidemiological studies and the treatment effects of n-3 PUFAs in the clinical trials was conducted. Moreover, recent experimental studies were also reviewed to explore the molecular mechanisms of the neuroprotective effects of n-3 PUFAs after stroke.