Electrophoretic identity of proteins in a finite population and genetic distance between taxa.
Electrophoretic identity of proteins in a finite population and genetic distance between taxa.
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有限群体中蛋白质的电泳鉴定和类群之间的遗传距离。
DOI：
10.1017/s0016672300016803
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
W.
中科院分区：
文献类型：
--
作者：
W.
Wehrhahn（1975）引入了概率母函数的方法来研究群体中同源蛋白质之间电荷差异的分布，但只考虑了群体从单个等位基因开始的特殊情况。然而，他的一些结果包含错误。本文给出了一般的、正确的、简单得多的公式。它也表明，扩散方程的方法（Ohta & Kimura，1973）可以产生相同的结果。数值计算表明，一步和两步电荷变化模型之间的差异几乎可以忽略不计。所得结果也被应用于Nei遗传距离的研究。数值计算表明，从电泳数据计算的遗传距离是约10%小于预期的氨基酸取代的数量，涉及电荷变化的早期阶段的群体的分歧，并可能给一个严重低估物种之间的比较。
Wehrhahn (1975) introduced the method of probability generating function to study the distribution of charge differences between homologous proteins in a population but considered only the special case where the population starts with a single allele. Some of his results, however, contained errors. In this paper, all the formulae are presented in general, correct yet much simpler forms. It is also shown that the method of diffusion equations (Ohta & Kimura, 1973) can produce the same results. Numerical computations show that the difference between the one-step and two-step models of charge changes is practically negligible. The results obtained have also been applied to study Nei's genetic distance. Numerical computations indicate that the genetic distance computed from electrophoretic data is about 10% smaller than the expected number of amino acid substitutions involving charge changes in the early stage of divergence of populations and may give a serious underestimate in comparisons between species.