Genome-wide analyses of introgression between two sympatric Asian oak species
Genome-wide analyses of introgression between two sympatric Asian oak species
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DOI：
10.1038/s41559-022-01754-7
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发表时间：
2022-05-05
影响因子：
16.8
通讯作者：
Chen, Jun
中科院分区：
文献类型：
--
作者：
Fu, Ruirui;Zhu, Yuxiang;Chen, Jun
在快速变化的环境中，导入可能是适应环境的新等位基因的重要来源，也许比立地变异更重要。尽管在许多植物和动物中已经进行了广泛的研究，但关于渗透的潜在机制的关键问题仍然没有得到解答。特别是，我们还没有确定沿基因组的导入区域的基因组分布；导入的程度和模式是否受到生态因素的影响；以及导入何时以及如何有助于适应。在这里，我们创建了两个同域分布的亚洲栎种的高质量基因组资源，分别在多个森林中采样，以研究它们之间的渗透。我们发现，导入区域广泛分布在整个基因组中。种群间的遗传差异以及它们所处环境的相似性都会影响入渗--拥有相似生态位置的种群往往共享相同的入渗区域。导入的适应基因组足迹优先位于重组率受抑制的区域。导入可能通过在顺式调节元件中引入等位变异，特别是通过转座元件插入，从而改变与逆境相关的基因的调节，从而在这些橡树种群中赋予适应性。我们的结果为揭示共生物种杂交适应机制提供了新的研究途径。导入是遗传变异的重要来源。通过对两个同域分布的亚洲栎种的基因组分析，作者发现了跨基因组的渐渗现象，并在重组率受到抑制的区域表现出适应性渐渗的特征。
Introgression can be an important source of new alleles for adaption under rapidly changing environments, perhaps even more important than standing variation. Though introgression has been extensively studied in many plants and animals, key questions on the underlying mechanisms of introgression still remain unanswered. In particular, we are yet to determine the genomic distribution of introgressed regions along the genome; whether the extent and patterns of introgression are influenced by ecological factors; and when and how introgression contributes to adaptation. Here, we generated high-quality genomic resources for two sympatric widespread Asian oak species, Quercus acutissima and Q. variabilis, sampled in multiple forests to study introgression between them. We show that introgressed regions are broadly distributed across the genome. Introgression was affected by genetic divergence between pairs of populations and by the similarity of the environments in which they live-populations occupying similar ecological sites tended to share the same introgressed regions. Introgressed genomic footprints of adaptation were preferentially located in regions with suppressed recombination rate. Introgression probably confers adaptation in these oak populations by introducing allelic variation in cis-regulatory elements, in particular through transposable element insertions, thereby altering the regulation of genes related to stress. Our results provide new avenues of research for uncovering mechanisms of adaptation due to hybridization in sympatric species.Introgression is an important source of genetic variation. Analysing genomes of two sympatric widespread Asian oak species, the authors find introgression across the genome and signatures of adaptive introgression in regions with suppressed recombination rate.