Animal Models of Tuberculosis: Guinea Pigs
Animal Models of Tuberculosis: Guinea Pigs
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DOI：
10.1101/cshperspect.a018572
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发表时间：
2015-05-01
影响因子：
5.4
通讯作者：
Williams, Ann
中科院分区：
文献类型：
--
作者：
Clark, Simon;Hall, Yper;Williams, Ann
豚鼠感染结核分枝杆菌后的疾病进展显示出人类结核病（TB）的许多特征，并且TB的豚鼠模型已被用作理解和描述疾病机制的研究工具超过100年。感染后细菌负荷和病理学的变化可以很容易地监测，并用于评估结核病干预措施的影响。在低剂量气溶胶豚鼠模型中证明疫苗的保护效力是开发中的新型疫苗的临床前数据包的重要组成部分，并且持续需要改进模型以促进疫苗向临床的进展。开发更好的工具来解剖豚鼠的免疫反应是当前研究的焦点。
The progression of the disease that follows infection of guinea pigs with Mycobacterium tuberculosis displays many features of human tuberculosis (TB), and the guinea pig model of TB has been used for more than 100 years as a research tool to understand and describe disease mechanisms. Changes in the bacterial burden and pathology following infection can be readily monitored and used to evaluate the impact of TB interventions. Demonstration of the protective efficacy of vaccines in the low-dose aerosol guinea pig model is an important component of the preclinical data package for novel vaccines in development, and there is a continual need to improve the model to facilitate progression of vaccines to the clinic. Development of better tools with which to dissect the immune responses of guinea pigs is a focus of current research.