Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats.
Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats.
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DOI：
10.1007/s12975-013-0270-5
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发表时间：
2013-10
影响因子：
6.9
通讯作者：
Xi, Guohua
中科院分区：
文献类型：
--
作者：
Hatakeyama, Tetsuhiro;Okauchi, Masanobu;Hua, Ya;Keep, Richard F.;Xi, Guohua
脑出血（ICH）主要是老年人的疾病。去铁胺（DFX）是一种铁螯合剂，可减轻老年大鼠脑出血后的长期神经功能缺损和脑萎缩。在本研究中，我们研究了DFX是否可以减少急性ICH诱导的神经元死亡，以及它是否影响老年大鼠对ICH的内源性反应（铁蛋白上调和血肿消退）。对雄性Fischer 344大鼠（18月龄）的右侧基底神经节进行尾内注射100 μL自体全血，并在ICH后2小时接受DFX（100 mg/kg）或溶剂处理，然后每12小时给药一次，直至7天。1、3或7天后对大鼠实施安乐死，以测量神经元死亡、铁蛋白和血肿大小。还检查了ICH后的血浆铁蛋白水平和行为结果。DFX治疗显著减少ICH诱导的神经元死亡和神经功能缺损。在ICH和血肿溶解后，DFX还抑制同侧基底神经节中的铁蛋白上调（第7天的血肿体积：13.2±4.9 mm 3对赋形剂治疗组中的3.8±1.2 mm 3，p < 0.01）。然而，DFX对ICH后血浆铁蛋白水平的影响未达到显著性。总之，DFX减少老年大鼠脑出血后神经元死亡和神经功能缺损。它还影响对ICH的内源性反应。
Intracerebral hemorrhage (ICH) is primarily a disease of the elderly. Deferoxamine (DFX), an iron chelator, reduces long-term neurological deficits and brain atrophy after ICH in aged rats. In the present study, we investigated whether DFX can reduce acute ICH-induced neuronal death and whether it affects the endogenous response to ICH (ferritin upregulation and hematoma resolution) in aged rats. Male Fischer 344 rats (18 months old) had an intracaudate injection of 100 μL autologous whole blood into the right basal ganglia and were treated with DFX (100 mg/kg) or vehicle 2 hours post-ICH and then every 12 hours up to 7 days. Rats were euthanized 1, 3, or 7 days later for neuronal death, ferritin and hematoma size measurements. Plasma ferritin levels and behavioral outcome following ICH were also examined. DFX treatment significantly reduced ICH-induced neuronal death and neurological deficits. DFX also suppressed ferritin upregulation in the ipsilateral basal ganglia after ICH and hematoma lysis (hematoma volume at day 7: 13.2±4.9 vs. 3.8±1.2 mm3 in vehicle-treated group, p < 0.01). However, effects of DFX on plasma ferritin levels after ICH did not reach significance. In conclusion, DFX reduces neuronal death and neurological deficits after ICH in aged rats. It also affects the endogenous response to ICH.
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影响因子：
8.3
作者：
Okauchi M;Hua Y;Keep RF;Morgenstern LB;Schallert T;Xi G
通讯作者：
Xi G
影响因子：
8.3
作者：
Mehdiratta, Manu;Kumar, Sandeep;Selim, Magdy
通讯作者：
Selim, Magdy
影响因子：
4.1
作者：
Nakamura, T;Keep, RF;Xi, GH
通讯作者：
Xi, GH
影响因子：
2.9
作者：
Nakamura, T;Keep, RF;Xi, GH
通讯作者：
Xi, GH
影响因子：
8.3
作者：
PALMER, C;ROBERTS, RL;BERO, C
通讯作者：
BERO, C