gamma-Aminobutyric acid action in guinea-pig ileal myenteric plexus.
gamma-Aminobutyric acid action in guinea-pig ileal myenteric plexus.
复制标题
γ-氨基丁酸在豚鼠回肠肌间神经丛中的作用。
DOI：
10.1016/0014-2999(82)90573-8
复制
发表时间：
1982
影响因子：
5
通讯作者：
Triggle,DJ
中科院分区：
文献类型：
--
作者：
Kaplita,PV;Waters,DH;Triggle,DJ
本文观察了γ-氨基丁酸（GABA）及其类似物对豚鼠回肠肌间神经丛-纵肌标本的直接刺激和电刺激反应。GABA，蝇蕈醇和3-氨基丙磺酸（3-APS），但不是巴氯芬，产生了短暂的，浓度依赖性的收缩，然后放松。阿托品、河豚毒素、甲碘荷包牡丹碱和印防己毒素可拮抗这些反应。对GABA和3-APS的反应表现出明显的快速耐受。GABA和巴氯芬，但不是蝇蕈醇或3-APS，产生了松弛作用的收缩引起的超大场刺激在纵向肌肉。这些反应是不敏感的荷包牡丹碱，荷包牡丹碱甲碘和印防己毒素，并不受其他药物，包括肾上腺素能，胆碱能和组胺拮抗剂。结果表明，GABA及其类似物作用于一群兴奋性受体，介导肠神经元释放乙酰胆碱，并作用于一群抑制性受体，抑制乙酰胆碱的刺激释放。
The responses of the guinea-pig ileum myenteric plexus-longitudinal muscle preparation to γ-aminobutyric acid (GABA) and several analogs were examined in direct and electrically stimulated preparations. GABA, muscimol and 3-aminopropane sulfonic acid (3-APS), but not baclofen, produced a transient, concentration-dependent contraction followed by relaxation. These responses were antagonized by atropine, tetrodotoxin, bicuculline methiodide and picrotoxin. Responses to GABA and 3-APS exhibited a marked tachyphylaxis. GABA and baclofen, but not muscimol or 3-APS, exerted a relaxant effect on contractions induced by supramaximal field stimulation in the longitudinal muscle. These responses were insensitive to bicuculline, bicuculline methiodide and picrotoxin, and were unaffected by other pharmacological agents including adrenergic, cholinergic and histamine antagonists. The results suggest that GABA and its analogs act at a population of excitatory receptors mediating the release of acetylcholine from enteric neurons, and at a population of inhibitory receptors which inhibit the stimulated release of acetylcholine.