SENSORY PROCESSING AND COROLLARY DISCHARGE EFFECTS IN THE MORMYROMAST REGIONS OF THE MORMYRID ELECTROSENSORY LOBE .1. FIELD POTENTIALS, CELLULAR-ACTIVITY IN ASSOCIATED STRUCTURES
SENSORY PROCESSING AND COROLLARY DISCHARGE EFFECTS IN THE MORMYROMAST REGIONS OF THE MORMYRID ELECTROSENSORY LOBE .1. FIELD POTENTIALS, CELLULAR-ACTIVITY IN ASSOCIATED STRUCTURES
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DOI：
10.1152/jn.1992.68.3.843
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发表时间：
1992-09-01
影响因子：
2.5
通讯作者：
SERRIER, J
中科院分区：
文献类型：
--
作者：
BELL, CC;GRANT, K;SERRIER, J
1.这是关于Mormyridae科电鱼的电感觉叶和密切相关结构的系列论文中的第一篇。这项研究描述了神经元对感觉刺激的反应，以及与驱动电器官放电（EOD）的运动命令相关的必然放电信号。该研究的重点是电感觉叶的区域，其中来自mormyromast电感受器的初级传入纤维终止。2.本系列的第一篇论文描述了小脑尾叶和电感觉叶的场电位。它还描述了小脑尾叶中不同类型的单位活动。小脑尾叶的颗粒细胞为电感觉叶的大部分分子层提供平行纤维。因此，确定这些细胞的输入和反应是理解电感觉叶的努力的重要组成部分。由EOD运动命令诱发的必然放电场电位在小脑尾叶和电感觉叶中非常突出。这些电位表明，必然的放电兴奋首先影响尾叶的颗粒细胞，然后，几毫秒后，影响电感觉叶的更深的细胞层。场电位的显著性和复杂性表明，伴随放电信号在长颌鱼感觉叶处理感觉电信息过程中具有重要而多样的作用.由电感觉刺激诱发的场电位表明，直接初级传入兴奋仅限于电感觉叶的颗粒层和中间层，这也由解剖学研究表明。本体感受单位是在小脑尾叶的颗粒细胞区域（后颗粒隆起）中记录的最常见类型的单位。这些单位有一个定期的放电率，改变紧张性的反应轻微弯曲的躯干，弯曲的尾巴，或弯曲的个别鳍。本体感受输入将对电感觉叶的分子层具有强烈的影响，并且因此将调节电感觉叶细胞对电感觉刺激的响应。这种对电感觉叶的本体感觉输入将允许身体位置变化的预期效果在电感觉信息的处理中被考虑。单位刻板，短潜伏期的必然放电爆发EOD运动命令是下一个最常见的类型的单位在隆起后。这些必然的放电单位不受感官刺激。这些单位可能介导了颗粒细胞的短潜伏期必然放电兴奋，场电位记录也表明了这一点。颗粒后隆突中的其他类型的单位包括：EOD运动命令的长潜伏期和可变爆发的必然放电单位; EOD运动命令后不同持续时间的刻板停顿的必然放电单位;以及响应沿着躯干的水运动的机械侧线单位。这些类型的单位也将影响通过轴突的颗粒细胞，在分子层中的平行纤维结束的电感叶。8.尾叶分子层的浦肯野细胞可通过其特有的攀缘纤维反应来识别。攀缘纤维反应和浦肯野细胞的普通锋电位都受到相应放电信号和电刺激的影响.小脑尾叶和电感觉叶之间的生理结果和密切的解剖学相似性表明，颗粒细胞区和尾叶的分子层在处理电感觉信息中起作用。
1. This is the first of a series of papers on the electrosensory lobe and closely associated structures in electric fish of the family Mormyridae. The study describes the neuronal responses to sensory stimuli and to corollary discharge signals associated with the motor command that drives the electric organ discharge (EOD). The study is focused on the regions of the electrosensory lobe where primary afferent fibers from mormyromast electroreceptors terminate.2. This first paper of the series describes the field potentials in the caudal lobe of the cerebellum and in the electrosensory lobe. It also describes the different types of unit activity in the caudal lobe of the cerebellum. Granule cells of the caudal lobe of the cerebellum provide the parallel fibers for most of the molecular layer of the electrosensory lobe. Determination of the input and responses of these cells is therefore an important part of the effort to understand the electrosensory lobe.3. Corollary discharge field potentials evoked by the EOD motor command are very prominent in the caudal lobe of the cerebellum and in the electrosensory lobe. The potentials indicate that corollary discharge excitation affects first the granule cells of the caudal lobe and then, a few milliseconds later, the deeper cellular layers of the electrosensory lobe. The prominence and complexity of the field potentials indicate that corollary discharge signals have an important and varied role in the processing of electrosensory information by the mormyrid electrosensory lobe.4. The field potentials evoked by electrosensory stimuli suggest that direct primary afferent excitation is limited to the granule and intermediate layers of the electrosensory lobe, as is indicated also by anatomic studies.5. Proprioceptive units are the most common type of unit recorded in the granule cell region of the caudal lobe of the cerebellum (eminentia granularis posterior). These units have a regular discharge rate that changes tonically in response to slight bending of the trunk, bending of the tail, or bending of individual fins. Proprioceptive input will have a strong effect on the molecular layer of the electrosensory lobe and will thus modulate the responses of electrosensory lobe cells to electrosensory stimuli. Such proprioceptive input to the electrosensory lobe would allow the expected effects of body position changes to be accounted for in the processing of electrosensory information.6. Units with stereotyped, short-latency corollary discharge bursts to the EOD motor command were the next most common type of unit in the eminentia granularis posterior. These corollary discharge units were not affected by sensory stimuli. These units probably mediate the short-latency corollary discharge excitation of the granule cells that was also indicated by the field-potential recordings.7. Additional types of units in the eminentia granularis posterior included the following: corollary discharge units with long latencies and variable bursts to the EOD motor command; corollary discharge units with stereotyped pauses of various durations following the EOD motor command; and mechanical lateral line units responding to water movement along the trunk. These types of units will also affect the electrosensory lobe via the axons of granule cells that end as parallel fibers in the molecular layer.8. Purkinje cells of the caudal lobe molecular layer could be identified by their characteristic climbing fiber responses. Both the climbing fiber responses and the ordinary spikes of Purkinje cells were affected by corollary discharge signals and by electrosensory stimuli.9. The physiological results and the close anatomic parallels between the caudal lobe of the cerebellum and the electrosensory lobe indicate that both the granule cell region and the molecular layer of the caudal lobe have roles in the processing of electrosensory information.