Mitochondrial noncoding RNA transport.
Mitochondrial noncoding RNA transport.
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DOI：
10.5483/bmbrep.2017.50.4.013
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发表时间：
2017-04
期刊：
影响因子：
3.8
通讯作者：
Gorospe M
中科院分区：
文献类型：
--
作者：
Kim KM;Noh JH;Abdelmohsen K;Gorospe M
线粒体是产生能量和维持细胞稳态所必需的细胞器。尽管线粒体基因组表达的少数蛋白质具有关键功能，但它们不足以维持线粒体的结构或活性。因此，线粒体代谢完全依赖于核DNA编码的因子，包括许多在细胞质中合成并通过既定机制导入线粒体的蛋白质。然而，越来越多的证据表明，哺乳动物线粒体也可以通过鲜为人知的过程输入细胞质非编码RNA。在这里，我们总结了我们对线粒体RNA的了解，讨论了最近在理解RNA输入线粒体的分子机制和功能影响方面的进展，并确定了这一快速发展领域的挑战和机遇。
Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized in the cytosol and imported into mitochondria via established mechanisms. However, there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes. Here, we summarize our knowledge of mitochondrial RNA, discuss recent progress in understanding the molecular mechanisms and functional impact of RNA import into mitochondria, and identify rising challenges and opportunities in this rapidly evolving field.