Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
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DOI：
10.1016/s0031-9422(02)00519-8
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发表时间：
2003-02-01
期刊：
影响因子：
3.8
通讯作者：
Chou, CJ
中科院分区：
文献类型：
--
作者：
Lin, LC;Yang, LL;Chou, CJ
从白花菜根中分离得到2个白藜芦酸糖苷：3‘-O-β-吡喃葡萄糖基白花酸和3’-O-β-吡喃葡萄糖基白花酸甲酯，以及5个萘醌类化合物(白藜芦素、壳寡糖酮、马利酮、椭圆酮和异黄酮酮)和5个香豆素类化合物(芝麻素、5-甲氧基倍半乳糖、山梨醇、黄百合和黄氧基)。以前并没有在这种植物中发现所有的香豆素。研究了这些化合物对多种肿瘤细胞系的细胞毒作用，发现白花蛇舌素对Raji、Calu-1、HeLa和Wish肿瘤细胞株的生长均有明显的抑制作用。(C)2002爱思唯尔科学有限公司。保留所有权利。
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to Various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.