Ultrasonic characterization of complete anisotropic elasticity coefficients of compressed oral solid dosage forms
Ultrasonic characterization of complete anisotropic elasticity coefficients of compressed oral solid dosage forms
复制标题
压缩口服固体剂型完全各向异性弹性系数的超声表征
DOI：
10.1016/j.ijpharm.2022.121922
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发表时间：
2022
影响因子：
5.8
通讯作者：
Cetinkaya, Cetin
中科院分区：
文献类型：
--
作者：
Sultan, Tipu;Paul, Shubhajit;Hasan Rozin, Enamul;Canino, Christian;Tseng, Yin-Chao;Cetinkaya, Cetin
在压实的材料中，弹性各向异性与残余应力相结合，可以在各种类型的缺陷，如封盖和层压的表现中发挥决定性作用，因为它会产生剪切面/带和时间松弛。这种内部微观结构导致延迟的裂纹萌生/形成、在残余应力下的裂纹尖端扩展以及最终的产品质量故障。因此，它们的准确表征和变化对于理解潜在的故障机制以及在故障发生之前在生产期间监测材料、工艺和产品质量的变化是有用的。片剂各向异性弹性性质的提取是一项具有挑战性的任务，特别是对于具有复杂形状的商业片剂，因为形状通常阻止使用传统的破坏性技术（例如，直径压缩测试仪）以产生精确的测量。本研究介绍并应用超声波方法提取完整的横观各向同性弹性性能的压缩口服固体剂型的商业片剂产品。一套完整的波形和本构矩阵的压实材料的报告。此外，进行了摄动分析，以解析地将各个方向上的传播速度与弹性系数相关联。所提出的表征方法是非破坏性的，快速，简便，可靠的评价片剂的各向异性。
In compacted materials, elastic anisotropy coupled with residual stresses could play a determining role in the manifestation of various types of defects such as capping and lamination, as it creates shear planes/bands and temporal relaxation. This internal micro-structure leads to time-delayed flaw initiation/formation, crack tip propagation under residual stresses, and ultimately product quality failures. Thus, their accurate characterization and variations are useful for understanding underlying failure mechanisms and to monitor variations in materials, processes and product quality during production prior to onset of failure. The extraction of tablet anisotropic elasticity properties is a challenging task, especially for commercial tablets with complex shapes, as shape often prevents the use of traditional destructive techniques (e.g., diametric compression testers) to produce accurate measurements. This study introduces and applies an ultrasonic approach to extracting the complete transverse isotropic elastic properties of compressed oral solid dosage forms to a commercial tablet product. A complete set of waveforms and the constitutive matrix for the compacted materials are reported. In addition, a perturbation analysis is carried out to analytically relate propagation speeds in various directions to the elastic coefficients. The proposed characterization approach is non-destructive, rapid, easy, and reliable in evaluating tablet anisotropy.