RNA-directed DNA methylation: an epigenetic pathway of increasing complexity
RNA-directed DNA methylation: an epigenetic pathway of increasing complexity
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DOI：
10.1038/nrg3794
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发表时间：
2014-07
影响因子：
42.7
通讯作者：
M. Matzke;R. Mosher
中科院分区：
文献类型：
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作者：
M. Matzke;R. Mosher
RNA指导的DNA甲基化（RdDM）是植物中主要的小RNA介导的表观遗传途径。RdDM需要一个专门的转录机制，包括两个植物特异性RNA聚合酶- Pol IV和Pol V -和越来越多的辅助蛋白，其在RdDM机制中的功能仅部分了解。最近的工作揭示了经典RdDM途径的变化，并确定了将Pol IV和Pol V招募到特定靶序列的因素。RdDM转录抑制转座子和基因的子集，涉及病原体防御，应激反应和繁殖，以及等位基因间和细胞间通讯。
RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases — Pol IV and Pol V — and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pol IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication.