Sorbitol dehydrogenase deficiency in several pig tissues: potential implications for studies of experimental diabetes
Sorbitol dehydrogenase deficiency in several pig tissues: potential implications for studies of experimental diabetes
复制标题
几种猪组织中山梨醇脱氢酶缺乏：对实验性糖尿病研究的潜在影响
DOI：
10.1007/bf00273916
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发表时间：
1984
期刊：
影响因子：
8.2
通讯作者：
J. Cantú
中科院分区：
文献类型：
--
作者：
G. Vaca;R. Alonso;P. Zúñiga;G. Gonzalez‐Quiroga;M. Chavez;C. Medina;C. Wunsch;J. Cantú
在12种不同的哺乳动物中进行了红细胞山梨醇脱氢酶缺乏症的筛查。在猪中观察到红细胞山梨醇脱氢酶存在广泛的种间变异性，几乎完全缺乏。还测定了12种不同组织中的醛糖还原酶和山梨醇脱氢酶活性。醛糖还原酶活性存在于研究的所有组织中，而观察到山梨醇脱氢酶的器官特异性。在晶状体和其他组织中未检测到山梨醇脱氢酶活性，使猪成为实验性糖尿病研究的潜在模型，特别是用于研究山梨醇脱氢酶缺乏症作为白内障发生的风险因素。
Screening for red blood cell sorbitol dehydrogenase deficiency in 12 different mammalian species was performed. A wide inter-species variability in red cell sorbitol dehydrogenase with a virtually complete deficiency in pigs was observed. Aldose reductase and sorbitol dehydrogenase activities in 12 different pig tissues also were measured. Aldose reductase activity was present in all the tissues studied, whereas organ specificity for sorbitol dehydrogenase was observed. Sorbitol dehydrogenase activity was not detectable in lenses, among other tissues, making the pig a potential model for studies in experimental diabetes, particularly for the investigation of sorbitol dehydrogenase deficiency as a risk factor in the development of cataracts.