Effects of environmental enrichment and social isolation on sucrose consumption and preference: Associations with depressive-like behavior and ventral striatum dopamine
Effects of environmental enrichment and social isolation on sucrose consumption and preference: Associations with depressive-like behavior and ventral striatum dopamine
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DOI：
10.1016/j.neulet.2008.03.045
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发表时间：
2008-05-09
影响因子：
2.5
通讯作者：
Fornaguera, Jaime
中科院分区：
文献类型：
--
作者：
Brenes, Juan C.;Fornaguera, Jaime
除了众所周知的环境丰富和社会隔离对药物自我给药和对精神兴奋剂的运动敏感性的影响外，很少有人注意到环境控制对自然奖励的敏感性及其与其他动机行为的可能关系。在这里，我们调查这些饲养条件对蔗糖消费和偏好，以及纹状体多巴胺的组织水平的影响。通过相关和回归分析，探讨了蔗糖摄入量、强迫游泳不动行为和多巴胺浓度之间的可能关系。尽管所有动物都喜欢蔗糖而不是水，但我们发现，在出生后期间，隔离大鼠比对照组或丰富的同窝出生大鼠消耗更多的蔗糖。在孤立的脂肪蔗糖摄入量呈正相关腹侧，但不与背侧纹状体多巴胺，即使纹状体多巴胺组间没有差异。特别是在孤立的动物不动的行为是积极的预测蔗糖摄入量的差异。多巴胺浓度与不动行为无关。总之，目前的数据支持以前的研究结果，早期生活事件后奖励敏感性和抑郁样行为的影响，也提供了进一步的证据，这些动机行为之间的关系和腹侧纹状体多巴胺在调节它们的可能作用。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
Little attention has been directed towards environmental control of sensitivity to natural reward and its possible relationship with other motivated behaviors, besides the well-known effects of environmental enrichment and social isolation on drug self-administration and locomotor sensitization to psychostimulants. Here, we investigate the effects of these rearing conditions on sucrose consumption and preference, and tissue levels of striatal dopamine. The possible relationship among sucrose intake, immobility behavior in the forced swimming test, and dopamine concentration was explored through correlation and regression analyses. Even though all animals preferred sucrose over water, we found, that during postnatal period, isolated rats consumed more sucrose than control or enriched littermates. In isolated Fats sucrose intake correlated positively with ventral but not with dorsal striatum dopamine, even when striatal dopamine did not differ among groups. Especially in isolated animals immobility behavior was positively predicted by differences in sucrose intake. The dopamine concentration did not correlate with immobility behavior. Taken together, the present data support previous findings regarding the effects of early life events upon reward-sensitivity and depressive-like behavior, and also provide further evidence about the relationship between these motivated behaviors and the likely role of ventral striatum dopamine in regulating them. (c) 2008 Elsevier Ireland Ltd. All rights reserved.