A histopathological study of esophageal cancer on the western side of the Caspian littoral from 1994 to 2003
A histopathological study of esophageal cancer on the western side of the Caspian littoral from 1994 to 2003
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DOI：
10.1111/j.1442-2050.2007.00776.x
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Abbasi, M.
中科院分区：
文献类型：
--
作者：
Gholipour, C.;Shalchi, R. A.;Abbasi, M.
食管癌（EC）在里海沿岸的人口中占上消化道癌的相当大的比例。近年来，该病的全球组织学模式发生了变化。本研究的目的是确定过去十年里海沿岸的西侧东阿塞拜疆（伊朗西北部省份）EC的发病率，并评估该疾病组织学模式的变化。在一项回顾性研究中，所有1792例记录EC病例的所有登记的癌症，外科，病理学和放射治疗中心的省超过9年（1994年3月至2003年3月）参加了这项研究。记录了有关人口统计学特征、EC危险因素和组织学结果的数据。确定了该省人群中EC病理亚型的发病率和相对发病率。评估了研究期间发病率的变化以及患者主要危险因素与肿瘤组织学之间的相互作用。全省30岁以上人群EC的平均发病率为16.2例/10万人年（鳞状细胞癌12.7例/10万人年，腺癌1.9例/10万人年）。SCC和AC的发病率在65岁以上达到峰值。与女性相比，男性AC的发病率较高，SCC的发病率较低; EC的平均发病率在男性和女性中相等。AC和SCC分别占病例的12.8%和86.9%。肿瘤位于食管上、中、下3/3分别占9.8%、32.9%和57.3%。在研究期间，EC和SCC的发病率呈下降趋势。1995 ~ 1998年食管癌发病率比1999 ~ 2002年高近30%。里海西部沿岸的EC发病率较高，但远低于30年前里海东部沿岸的。EC的发生率在研究期的后半期低于前半期。与EC的全球模式不同，女性EC和SCC的发病率与男性一样高或高于男性，这与东里海沿岸的模式相同。
Esophageal cancer (EC) accounts for a considerable proportion of carcinomas of the upper gastrointestinal tract in the population of the Caspian littoral. The global histologic pattern of the disease has changed recently. The intent of this study was to determine the incidence of EC over the past decade in Eastern Azerbaijan - a north-western province of Iran - on the western side of the Caspian littoral and to assess the alteration of the histological pattern of the disease. In a retrospective study, all 1792 documented EC cases of all registered cancer, surgery, pathology, and radiotherapy centers of the province over a period of 9 years (from March 1994 to March 2003) were enrolled in the study. Data concerning demographic characteristics, EC risk factors, and histological findings were recorded. The incidence and the relative incidence of the pathological subtypes of EC in the population of the province were determined. The change in incidence rates and the interaction between main risk factors and tumor histology of the patients were assessed over the study years. The average incidence of EC in the over 30-year-old population of the province was 16.2 (12.7 for squamous cell carcinoma [SCC] and 1.9 for adenocarcinoma [AC]) cases per 100 000 person-years. Incidence of SCC, as well as AC, peaked at ages older than 65. Compared to women, men had higher incidences of AC and lower incidences of SCC; the average incidence rate of EC was equal in men and women. AC and SCC accounted for 12.8% and 86.9% of cases, respectively. Upper, middle and lower thirds of the esophagus were the location of tumors in 9.8%, 32.9% and 57.3% of cases, respectively. During the study period, incidence rates of EC and SCC tended to decrease. The incidence rate of EC from 1995 to 1998 was almost 30% higher than that of the period from 1999 to 2002. Incidence rate of EC on the western side of the Caspian littoral is moderately high, but much lower than that of the eastern Caspian littoral as it was three decades ago. The incidence of EC was lower in the second half than the first half of the study period. Unlike the global pattern of EC, the incidence of EC as well as SCC in women is as high as or higher than in men, which is identical to the pattern in the eastern Caspian littoral.