GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition
GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition
复制标题
GGP 修饰的柔红霉素加薯蓣皂苷脂质体通过抑制上皮间质转化抑制乳腺癌
DOI：
10.1080/03639045.2020.1763397
复制
发表时间：
2020
影响因子：
3.4
通讯作者：
Li Xue-tao
中科院分区：
文献类型：
--
作者：
Yao Xue-min;Niu Feng-ju;Kong Liang;Cai Fu-yi;Jing Ming;Fu Min;Liu Jing-jing;He Si-yu;Zhang Lu;Liu Xin-ze;Ju Rui-jun;Li Xue-tao
肿瘤的侵袭和转移是抗肿瘤治疗的难点。上皮细胞间质转化被广泛认为是乳腺癌侵袭和转移的关键步骤之一。在本研究中，GGP修饰柔红霉素加薯蓣皂苷脂质体的构建和表征。GGP修饰的柔红霉素-薯蓣皂苷脂质体粒径合适，PDI窄，zeta电位约为-5 mV，周期效应长，且由于GGP的表面修饰，使脂质体能进入肿瘤内部，充分发挥其抗肿瘤作用。体外实验结果表明，脂质体对肿瘤细胞有上级杀伤作用，体内实验结果表明，脂质体能延长药物在体内的滞留时间，并在肿瘤部位蓄积，全身毒性小。总之，靶向脂质体能有效抑制肿瘤侵袭，可能为浸润性乳腺癌的治疗提供新的策略。
Tumor invasion and metastasis are the nodus of anti-tumor. Epithelial cell–mesenchymal transition is widely regarded as one of the key steps in the invasion and metastasis of breast cancer. In this study, GGP modified daunorubicin plus dioscin liposomes are constructed and characterized. GGP modified daunorubicin plus dioscin liposome has suitable particle size, narrow PDI, zeta potential of about –5 mV, long cycle effect, and enhanced cell uptake due to surface modification of GGP making the liposome could enter the inside of the tumor to fully exert its anti-tumor effect. The results ofin vitroexperiments show that the liposome has superior killing effect on tumor cells and invasion.In vivoresults indicate that the liposome prolongs the drug’s prolonged time in the body and accumulates at the tumor site with little systemic toxicity. In short, the targeted liposome can effectively inhibit tumor invasion and may provide a new strategy for the treatment of invasive breast cancer.