Solitary plasmacytoma of bone and extramedullary plasmacytoma
Solitary plasmacytoma of bone and extramedullary plasmacytoma
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DOI：
10.1016/s0889-8588(05)70124-6
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发表时间：
1999-12-01
影响因子：
2.4
通讯作者：
Moulopoulos, LA
中科院分区：
文献类型：
--
作者：
Dimopoulos, MA;Kiamouris, C;Moulopoulos, LA
骨孤立性浆细胞瘤发生在浆细胞骨髓瘤患者的约5%。现代技术，包括磁共振成像和在形态正常的骨髓中寻找单克隆浆细胞，可以识别出真正局限性疾病的患者。4500 cGy剂量的放射治疗通常可以根除肿瘤，并且与许多患者的无病生存期延长相关。髓外浆细胞瘤较骨孤立性浆细胞瘤少见，多发生于头颈部。放射治疗与非常高的局部控制率相关，并且不到30%的患者发生远处复发。髓外浆细胞瘤预后好于骨孤立性浆细胞瘤。
Solitary plasmacytoma of bone occurs in about 5% of patients with plasma cell myeloma. Modern techniques, including magnetic resonance imaging and the search for monoclonal plasma cells in morphologically normal bone marrow, may allow the identification of patients with truly localized disease. Radiotherapy at a dose of 4500 cGy usually eradicates the tumor and is associated with prolonged disease-free survival in many patients. Extramedullary plasmacytoma is less common than solitary plasmacytoma of bone and more frequently occurs in the head and neck area. Radiotherapy is associated with a very high local control rate, and less than 30% of patients develop a distant relapse. The prognosis of extramedullary plasmacytoma is better than that of solitary bone plasmacytoma.