Targeted Mutations in Integrins and their Ligands: Their Implications for Vascular Biology
Targeted Mutations in Integrins and their Ligands: Their Implications for Vascular Biology
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整合素及其配体的靶向突变：它们对血管生物学的影响
作者：
R. Hynes;B. Bader
细胞之间的粘附以及细胞与下面或周围的细胞外基质的粘附在所有后生细胞的发育、生理学和病理学中起着至关重要的作用。这对于血管和其他任何地方都是如此。事实上，在血管生物学的背景下，细胞粘附已被最有效地粉碎。我们对血管细胞的细胞粘附的了解比其他任何细胞都多，并且其中提出的概念可以作为思考其他情况下细胞粘附的模型（l）。在脉管系统的发育过程中，细胞粘附在心脏和血管的组装中发挥作用。细胞需要迁移到正确的位置并组装成管，管需要正确排列。这些形态发生事件依赖于细胞粘附；细胞+细胞和细胞-基质。如果在发育过程中粘连调节不当，就会导致心脏或血管异常。在脉管系统的正常功能期间，循环细胞（例如淋巴细胞）在身体周围运输时需要粘附在适当的位置。为了应对感染或损伤，白细胞需要在感染部位粘附和渗出，血小板需要粘附到受损的血管壁上并相互粘附以防止出血。当这些冲突过程有缺陷时，就会导致疾病；分别对感染或出血的易感性。血细胞粘附缺陷是有害的，但过度粘附也是有害的。白细胞或血小板的不适当粘附可分别导致炎症或血栓形成。因此，粘合必须牢固
Adhesion of cells to one another and to the underlying or surounding extracellular mahix plays crucial roles in the development, physiology andpathology of all metazmns. This is as true in the vasculahrre as anywhere else. Indeed, cell adhesion has been most effectively shrdied in the context of vascular biology; we know more about cell adhesion of vascular cells than about any others and the concepts developed there serve as models for thinking about cell adhesion in other contexts (l). During development of the vasculature, cell adhesion plays roles in the assembly of the heart and vessels; the cells need to migrate to the correct locations and assemble into tubes, which need to be arrayed correctly. These morphogenetic events rely on cell adhesion; both cell+ell and ceIl-matrix. If adhesion is improperly regulated during development, abnormalities in the heart or blood vessels can ensue. During normal functioning of the vasculature, circulating cells such as lymphocytes need to adhere in appropriate locations during their traffic around the body. In response to infection or injury, leukocytes need to adhere and extrava-sate at sites of infection and platelets need to adhere to damaged vessel walls and to each other to prevent bleeding. When these adtresion processes are defective, disease results; susceptibility to infections or bleeding, respectively. While defective adhesion of blood cells is deleterious, so is excessive adhesion. Inappropriate adhesion of leukocytes or platelets can lead to inflammation or thrombosis, respectively. Therefore, adhesion must be tightly
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基因打靶产生 CD18 突变小鼠用于炎症研究。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Wilson,RW;Ballantyne,CM;Smith,CW;Montgomery,C;Bradley,A;O'Brien,WE;Beaudet,AL
通讯作者：
Beaudet,AL
影响因子：
56.9
作者：
DAMERON, KM;VOLPERT, OV;BOUCK, N
通讯作者：
BOUCK, N
影响因子：
4.6
作者：
Joy T. Yang;H. Rayburn;R. Hynes
通讯作者：
Joy T. Yang;H. Rayburn;R. Hynes
影响因子：
10.5
作者：
GURTNER, GC;DAVIS, V;CYBULSKY, MI
通讯作者：
CYBULSKY, MI
通过选择性 RNA 剪接产生的鼠细胞间粘附分子 1 的新亚型。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
King,PD;Sandberg,ET;Selvakumar,A;Fang,P;Beaudet,AL;Dupont,B
通讯作者：
Dupont,B