Focus on hepatocellular carcinoma

Focus on hepatocellular carcinoma
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DOI:
10.1016/s1535-6108(04)00058-3
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发表时间:
2004-03-01
期刊:
影响因子:
50.3
通讯作者:
Llovet, JM
Llovet, JM
中科院分区:
医学1区
文献类型:
--
作者:
Bruix, J;Boix, L;Llovet, JM

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肝细胞癌(HCC)是全世界第五常见的肿瘤(> 500,000例死亡/年),并且在世界的一些地区,它代表癌症相关死亡的主要原因(Parkin et al.,2001年)的报告。多年前,HCC被认为是亚洲和非洲的主要健康问题,在欧洲或美洲的发病率较低。然而,目前的数据表明,其发病率在西方稳步上升(Parkin等人,2001年)。这引起了对其分子发病机制以及流行病学和治疗相关方面的关注。该重点总结了有关这些问题的现有知识,并指出了最活跃的研究领域,迫切需要强有力的数据。
Hepatocellular carcinoma (HCC) is the fifth most frequent neoplasm worldwide (> 500,000 deaths/year), and in some areas of the world it represents the primary cause of cancer-related death (Parkin et al., 2001). Years ago, HCC was considered a major health problem in Asia and Africa, with minor prevalence in Europe or America. However, current data indicate that its incidence is steadily increasing in the West (Parkin et al., 2001). This has raised the attention paid to its molecular pathogenesis and to aspects related to epidemiology and treatment. This focus summarizes the established knowledge regarding these issues and points out the most active areas of research where strong data are eagerly awaited.