Tumour Cell Death: the Probable Cause of Increased Polyamine Levels in Physiological Fluids
Tumour Cell Death: the Probable Cause of Increased Polyamine Levels in Physiological Fluids
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肿瘤细胞死亡：生理液中多胺水平升高的可能原因
DOI：
10.1111/j.1699-0463.1978.tb02007.x
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
G. Andersson
中科院分区：
文献类型：
--
作者：
O. Heby;G. Andersson
研究了荷埃利希腹水瘤小鼠细胞外多胺的发生与肿瘤生长的关系。发现无细胞腹水和血清中腐胺和亚精胺的浓度随着肿瘤质量的增加而显著增加。提出的数据表明，所观察到的细胞外多胺的积累是从死亡或垂死的肿瘤细胞的连续释放的结果。这一观察结果与细胞外多胺在肿瘤生长期间以及放疗和化疗后由于肿瘤细胞死亡而积累的观点一致，并强调了多胺分析在评估肿瘤细胞杀伤方面的潜在临床用途。
The occurrence of extracellular polyamines in Ehrlich ascites tumour‐bearing mice was studied in relation to tumour growth. The concentration of putrescine and spermidine in cell‐free ascites fluid and serum was found to increase significantly with increasing tumour mass. Data is presented which suggest that the observed accumulation of extracellular polyamines is a result of a continuous release from dead or dying tumour cells. This observation is consistent with the notion that extracellular polyamines accumulate during tumour growth and following radio‐ and chemotherapy as a result of tumour cell death, and emphasizes the potential clinical usefulness of the polyamine analysis for evaluating tumor cell kill.