Estimation of endogenous glucose production after a glucose perturbation by nonparametric stochastic deconvolution.
Estimation of endogenous glucose production after a glucose perturbation by nonparametric stochastic deconvolution.
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通过非参数随机反卷积估计葡萄糖扰动后内源性葡萄糖的产生。
DOI：
10.1016/s0169-2607(96)01784-1
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发表时间：
1997
影响因子：
6.1
通讯作者：
C. Cobelli
中科院分区：
文献类型：
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作者：
P. Vicini;G. Sparacino;A. Caumo;C. Cobelli
了解葡萄糖扰动后内源性葡萄糖产生（EGP）的时间过程对于理解健康和疾病（如糖尿病）状态下的葡萄糖调节系统至关重要。EGP不能直接获得，因此需要一种间接测量方法。静脉葡萄糖耐量试验（IVGTT）中EGP的估计可以作为一个输入估计问题，可求解为第一类Fredholm积分方程(a . Caumo和C. Cobelli, Am。j .杂志。， 264 (1993) e829-e841)。通过伴随示踪实验确定了葡萄糖系统核的时变模型，并采用philips - tikhonov正则化（反卷积）算法重构了EGP。然而，提出的反卷积方法留下了一些问题，例如如何选择正则化的量以及如何处理非均匀/不频繁的采样。本文提出了一种新的反卷积算法来解决这些问题。由于新的反卷积方法是随机嵌入的，因此正则化的数量以统计上合理的方式确定。此外，在采样频率较低的情况下，得到了EGP的时间连续剖面。结果表明，该方法在不同的IVGTT实验方案中都能可靠地重建正常和疾病状态下的EGP。
The knowledge of the time course of endogenous glucose production (EGP) after a glucose perturbation is crucially important for understanding the glucose regulation system in both healthy and disease (e.g. diabetes) states. EGP is not directly accessible, and thus an indirect measurement approach is required. The estimation of EGP during an intravenous glucose tolerance test (IVGTT) can be posed as an input estimation problem solvable as a Fredholm integral equation of the first kind (A. Caumo and C. Cobelli, Am. J. Physiol., 264 (1993) E829–E841). The time-varying model of the kernel of the glucose system was identified from a concomitant tracer experiment, and EGP was reconstructed by employing the Phillips-Tikhonov regularization (deconvolution) algorithm. However, the proposed deconvolution approach left some issues open, e.g. how to choose the amount of regularization and how to deal with nonuniform/infrequent sampling. Here, a solution to these problems is provided by resorting to a new deconvolution algorithm. Thanks to the stochastic embedding into which the new deconvolution method is stated, the amount of regularization is determined in a statistically sound manner. In addition, in face of infrequent sampling, a time continuous profile of EGP is obtained. The method is shown to work reliably for reconstructing EGP in different IVGTT experimental protocols, both in normal and disease states.
热而不是冷的最小模型可以精确评估 NIDDM 受试者的胰岛素敏感性。
DOI：
10.1152/ajpendo.1996.270.3.e532
发表时间：
1996
期刊：
The American journal of physiology.
影响因子：
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作者：
Avogaro,A;Vicini,P;Valerio,A;Caumo,A;Cobelli,C
通讯作者：
Cobelli,C