Macrophages and tuberculosis.
Macrophages and tuberculosis.
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DOI：
10.1097/00062752-199801000-00012
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发表时间：
1998-01-01
影响因子：
3.2
通讯作者：
Fenton, M J
中科院分区：
文献类型：
--
作者：
Fenton, M J
世界上几乎三分之一的人口感染了结核分枝杆菌（Mtb），这是结核病的病原体。全世界每年有800万新发肺结核病例，300万人死于该病。结核分枝杆菌是一种主要存在于巨噬细胞内的细胞内病原体。矛盾的是，巨噬细胞也代表了抵抗这种病原体的第一道防线。最近在了解结核分枝杆菌进入巨噬细胞，抑制宿主细胞的杀微生物活性，并最终破坏细胞介导的免疫反应以根除感染的机制方面取得了重大进展。本文综述了有助于我们理解单核吞噬细胞在抗结核免疫应答中所起作用的最新发现。
Almost one third of the world's population is infected with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Each year there are eight million new cases of tuberculosis and three million deaths from the disease worldwide. Mtb is an intracellular pathogen that resides predominantly within macrophages. Paradoxically, macrophages also represent the first line of defense against this pathogen. Significant recent advances have been made in understanding the mechanisms by which Mtb gains entry into the macrophage, suppresses the microbicidal activities of this host cell, and ultimately subverts cell-mediated immune responses that eradicate the infection. This article reviews recent findings that contribute to our understanding of the roles played by mononuclear phagocytes in the immune response against tuberculosis.