Cdc42 regulation of polarized traffic in fission yeast.
Cdc42 regulation of polarized traffic in fission yeast.
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DOI：
10.4161/cib.19977
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发表时间：
2012-07-01
影响因子：
--
通讯作者：
Perez, Pilar
中科院分区：
文献类型：
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作者：
Estravis, Miguel;Rincon, Sergio;Perez, Pilar
Cdc42是控制细胞极性和形态发生的关键因子。裂变酵母Cdc42调节双胍蛋白激活和肌动蛋白电缆组装。外囊功能也需要Cdc42，有助于极化分泌。此外，Cdc42参与膜运输、核内体循环和液泡形成。我们在这里展示了Cdc42是如何被正确运输/循环到葡聚糖合成酶Bgs1和Bgs4的质膜所需要的，Bgs1和Bgs4负责细胞壁的生物合成和细胞尖端的极化生长。
Cdc42 is a key factor in the control of cell polarity and morphogenesis. Fission yeast Cdc42 regulates formin activation and actin cable assembly. Cdc42 is also required for exocyst function, contributing to polarized secretion. Additionally, Cdc42 participates in membrane trafficking, endosome recycling, and vacuole formation. We show here how Cdc42 is required for the correct transport/recycling to the plasma membrane of the glucan synthases Bgs1 and Bgs4, responsible of cell wall biosynthesis and polarized growth at the cell tips.