Prefrontal morphology, 5-HTTLPR polymorphism and biased attention for emotional stimuli
Prefrontal morphology, 5-HTTLPR polymorphism and biased attention for emotional stimuli
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DOI：
10.1111/j.1601-183x.2009.00550.x
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发表时间：
2010-03-01
影响因子：
2.5
通讯作者：
Schnyer, D.
中科院分区：
文献类型：
--
作者：
Beevers, C. G.;Pacheco, J.;Schnyer, D.
对情绪刺激的偏见性注意与精神病理学的脆弱性有关。本研究探讨了偏向性注意的神经机制。23名成年女性完成了高分辨率结构成像，然后进行了标准的行为测量偏差注意（即空间线索任务）。参与者还对5-羟色胺转运蛋白相关启动子区（5-HTTLPR）基因进行了基因分型。结果表明，外侧前额叶皮层（LPFC）的形态与保持注意力的积极和消极的刺激，但只有在短5-HTTLPR等位基因携带者。而内侧前额叶皮层（mPFC）和杏仁核则没有发现这种关联。这项研究的结果表明，在短5-HTTLPR等位基因携带者中，参与情绪认知控制的大脑区域也与情绪刺激的注意力偏差有关。
Biased attention for emotional stimuli has been associated with vulnerability to psychopathology. This study examines the neural substrates of biased attention. Twenty-three adult women completed high-resolution structural imaging followed by a standard behavioral measure of biased attention (i.e. spatial cueing task). Participants were also genotyped for the serotonin transporter-linked promoter region (5-HTTLPR) gene. Results indicated that lateral prefrontal cortex (lPFC) morphology was inversely associated with maintained attention for positive and negative stimuli, but only among short 5-HTTLPR allele carriers. No such associations were observed for the medial prefrontal cortex (mPFC) or the amygdala. Results from this study suggest that brain regions involved in cognitive control of emotion are also associated with attentional biases for emotion stimuli among short 5-HTTLPR allele carriers.